Fig. 1.

(a) Chemotaxis capacity of peritoneal lymphocytes, (b) lymphoproliferation in ConA (1 μg/ml)-stimulated 48 h-culture supernatants, (c) lymphoproliferation in LPS (1 μg/ml)-stimulated 48 h-culture supernatants and (d) release of interleukin-2 (IL-2) in supernatants of 48 h-cultures of peritoneal leukocytes stimulated with Con A (1 μg/ml) from adult female ICR (CD-1) mice supplemented for 5 weeks with cereal fractions (B, C, D or E) naturally rich in polyphenols. Bars show the mean ± SD of eight values, corresponding to the same number of experiments, being each value the mean of duplicate assays. *P < 0.05 **P < 0.01 and ***P < 0.001 versus the control group. Lymphoproliferation in response to both mitogens, Con A and LPS, was expressed as % of stimulation with respect to spontaneous proliferation, the latter considered as 100. Spontaneous lymphoproliferation (in counts per min): Control = 1245 ± 253; B = 1348 ± 239; C = 1071 ± 171; D = 1186 ± 166; E = 1052 ± 169