TABLE 1.

O₂ diffusion constants in different zones of the micro models.

Region in the micro model	D0 [10−9 m2/s]		ρcell [106 cells/ml]	φ		Deff [10−9 m2/s]
	Cult. med.	Plasma				Cult. med.	Plasma
No hepatocytes
Inter-capillary space	2.92	2.18	0	0	1	2.92	2.18
In mat	2.48	1.85	0	0	1	2.48	1.85
Cell distribution 1
In mat	2.48	1.85	53.7	0.172	0.75	1.87	1.41
Cell distribution 2
In mat	2.48	1.85	31.7	0.102	0.85	2.11	1.59
In hepatocyte cell layer around capillaries – part in mat zone	2.48	1.85	81.7	0.262	0.64	1.59	1.22
In hepatocyte cell layer around capillaries – part in inter-capillary space	2.92	2.18	81.7	0.262	0.64	1.86	1.41

The ratio of the effective diffusion constant to the free diffusion constant D_eff/D₀ is calculated from the local free oxygen diffusion constant D₀ and the local cell volume fraction φ using Eq. 3. The local effective diffusion coefficients D_eff in culture medium and plasma per region are presented in the last column.