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. 2006 Oct 10;34(11):1729–1744. doi: 10.1007/s10439-006-9169-6

TABLE 2.

Overview of simulations.

Case Fluid pO2 gas (mmHg) pO2 medium (mmHg) Qmedium (ml/min) # capillaries KM (mmHg)
Reference case
    (1) Standard boundary conditions Culture medium 150 146.5 0.05 1 2
Effect of the internal oxygenator
    (2) pO2 gas = 0 Culture medium 0 146.5 0.05 1 2
    (3) pO2 gas = 0; pO2 medium × 2 Culture medium 0 293 0.05 1 2
Increasing oxygen availability
    (4) pO2 gas × 2 Culture medium 300 146.5 0.05 1 2
    (5) pO2 gas = carbogen Culture medium 722 146.5 0.05 1 2
    (6) pO2 medium × 2 Culture medium 150 293 0.05 1 2
    (7) pO2 medium = carbogen Culture medium 150 722 0.05 1 2
    (8) Fluid flow rate Qmedium × 2 Culture medium 150 146.5 0.10 1 2
    (9) Fluid flow rate Qmedium × 10 Culture medium 150 146.5 0.50 1 2
    (10) No. capill.  × 2 Culture medium 150 146.5 0.05 2 2
    (11) No. capill.  × 2; pO2 gas × 2 Culture medium 300 146.5 0.05 2 2
Clinical versus experimental setting
    (12) Plasma Plasma 150 146.5 0.05 1 2
    (13) Plasma; pO2 gas × 2 Plasma 300 146.5 0.05 1 2
Changes of hepatocyte O2 consumption in time
    (14) KM day 4 Culture medium 150 146.5 0.05 1 4.75
    (15) KM day 5 Culture medium 150 146.5 0.05 1 7.5

Each case is applied to the four basic micro model configurations (inline and triangular micro model each with cell distribution 1 or 2).