TABLE 4.
Percentages of total hepatocyte cell amount that attain a Vratio > 0.9.
| % Hepatocytes with Vratio > 0.9 | ||||||
|---|---|---|---|---|---|---|
| Case | Hepatocyte distribution 1 | Hepatocyte distribution 2 | ||||
| Inline (%) | Triangular (%) | Inline (%) | Triangular (%) | |||
| Mat (%) | Capill. (%) | Mat (%) | Capill. (%) | |||
| Reference case | ||||||
| (1) Standard boundary conditions | 15.7 | 15.8 | 28.8 | 28.6 | ||
| 3.3 | 54.1 | 3.3 | 53.5 | |||
| The effect of the internal oxygenator | ||||||
| (2) pO2 gas = 0 | 1.7 | 1.7 | 1.7 | 1.7 | ||
| 3.1 | 0.4 | 3.1 | 0.4 | |||
| (3) pO2 gas = 0; pO2 medium × 2 | 6.2 | 6.2 | 6.3 | 5.9 | ||
| 11.0 | 1.7 | 10.3 | 1.7 | |||
| Increasing oxygen availability | ||||||
| (4) pO2 gas × 2 | 30.4 | 30.2 | 50.3 | 50.3 | ||
| 5.1 | 95.1 | 5.0 | 94.9 | |||
| (5) pO2 gas = carbogen | 62.4 | 64.5 | 80.7 | 88.3 | ||
| 61.2 | 100.0 | 76.3 | 100.0 | |||
| (6) pO2 medium × 2 | 20.1 | 20.2 | 34.5 | 33.9 | ||
| 11.8 | 57.0 | 11.0 | 56.5 | |||
| (7) pO2 medium = carbogen | 35.5 | 35.1 | 54.2 | 53.4 | ||
| 40.6 | 67.7 | 37.5 | 69.1 | |||
| (8) Qmedium × 2 | 17.9 | 18.1 | 31.6 | 31.4 | ||
| 6.6 | 56.4 | 6.5 | 56.0 | |||
| (9) Qmedium × 10 | 28.4 | 28.6 | 45.7 | 45.6 | ||
| 22.2 | 68.9 | 22.1 | 68.9 | |||
| (10) No capillaries × 2 | 31.8 | 31.8 | 56.7 | 56.8 | ||
| 14.1 | 100.0 | 14.3 | 100.0 | |||
| (11) No capillaries × 2; pO2 gas × 2 | 61.0 | 59.9 | 87.5 | 84.8 | ||
| 75.3 | 100.0 | 69.9 | 100.0 | |||
| Clinical versus experimental setting | ||||||
| (12) Plasma | 12.0 | 12.0 | 22.9 | 23.0 | ||
| 2.6 | 43.0 | 2.6 | 43.0 | |||
| (13) Plasma; pO2 gas × 2 | 22.8 | 22.9 | 40.8 | 40.9 | ||
| 2.9 | 78.4 | 2.9 | 78.3 | |||
| Changes in hepatocyte O2 consumption in time | ||||||
| (14) KM day 4 | 8.7 | 8.7 | 18.9 | 18.9 | ||
| 1.1 | 36.4 | 1.1 | 36.4 | |||
| (15) KM day 5 | 5.0 | 5.1 | 12.9 | 13.0 | ||
| 0.3 | 25.3 | 0.3 | 25.5 | |||
In the case of hepatocyte distribution 2, distinction is made between the percentage of the total number of hepatocytes in the mat and the percentage of total number of hepatocytes in the cell layers around the capillaries.