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Representative intermolecular NOEs observed upon GAAA tetraloop–receptor complex formation. (A) Strips from 2D NOESY spectra showing intermolecular NOEs from the tetraloop to the receptor in presence of 10 mM Co(NH3)6 3+, 500 mM K+, and 16 mM Mg2+. (B) Portion of the tetraloop–receptor complex (PDB ID 2ADT) with the tetraloop shown in red and receptor in blue. Dashed lines represent intermolecular NOEs shown in (A) from A23H2 to: G8H1′ (violet), G9H1′ (orange), and G8H2′ (green).
