Skip to main content
. Author manuscript; available in PMC: 2006 Dec 19.
Published in final edited form as: J Biol Chem. 2002 Nov 20;278(7):5009–5020. doi: 10.1074/jbc.M210436200

Fig. 8.

Fig. 8

Model for VFT complex function in the Cvt pathway. The VFT complex, including Vps51, functions as a tethering factor that is required for retrieval (retrograde traffic) from the early endosome to the Golgi complex (33, 45, 46). In the Cvt pathway, mutations in the VFT proteins result in mislocalization of the PAS component Cvt9, suggesting a tethering role in anterograde transport from the Golgi complex to the PAS. By analogy with its role in retrieval from the endosome, it is also possible that the VFT complex is needed for retrograde recovery of certain components from the PAS. Most of the Apg/Cvt proteins that localize to the PAS are not found in completed Cvt vesicles suggesting that they are excluded from the vesicle and retained at the PAS or that they are recycled back to another compartment such as the Golgi complex. See text for details.