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. 2003 Jul 23;100(16):9168–9172. doi: 10.1073/pnas.1631716100

Fig. 2.

Fig. 2.

SK–Pg interactions. (A) A ribbon diagram illustrates the crystal structure of human Pg. The loop structures that contact the α and γ domains of SK are numbered and colored. This figure was produced by using molscript and raster3d (36, 37). (B and C) Activation of cow Pg, human micro-Pg, and chimeric micro-Pgs by SUPA (B) and SK (C). Human micro-Pg (300 nM), cow Pg (300 nM), and chimeric loop 5, 7, 9, 11 micro-Pg (300 nM) (or other chimeric micro-Pgs) were activated by SK (20 nM) or SUPA, as indicated. Pg activation was monitored as described in Fig. 1. (Inset) Activation of the loop 5, 7, 9, and 11 chimeric micro-Pg (300 nM) by urokinase (33 nM).