Table 1. Comparison of plasma levels of CGRP and cGMP elicited by 10-min infusion of NO and HNO donors.
|
Artery
|
Vein
|
||||||
|---|---|---|---|---|---|---|---|
| Donor | n | Infusion rate, μg/kg/min | Baseline | Post infusion | Baseline | Post infusion | |
| CGRP, pg/ml | AS | 7 | 10 | 25.8 ± 1.5 | 52.3 ± 4.7* | 27.8 ± 1.3 | 42.5 ± 1.3* |
| DEA/NO | 3 | 2 | 28.1 ± 3.2 | 30.6 ± 5.2 | 21.5 ± 1.5 | 22.0 ± 1.0 | |
| NTG | 4 | 10 | 29.4 ± 4.9 | 28.9 ± 2.6 | 26.3 ± 5.0 | 23.1 ± 6.1 | |
| total | 42 | 28.5 ± 1.1 | 28.3 ± 1.2 | ||||
| cGMP, nM | AS | 6 | 10 | 22.5 ± 8.5 | 20.2 ± 5.7 | 20.3 ± 8.1 | 23.2 ± 8.2 |
| DEA/NO | 1 | 3.1 | 16.1 | 66.9 | 26.7 | 65.4 | |
| NTG | 1 | 3.3 | 29.7 | 49.3 | 27.3 | 45.4 | |
| NTG | 1 | 10 | 30.6 | 52.6 | 28.5 | 52.5 | |
| NTG | 1 | 16 | 29.7 | 63.0 | 27.3 | 70.1 | |
*
P < 0.01 vs. baseline. Coronary sinus data are provided in the supporting information.