Table 1. Malignancies in Bad-deficient mice.
No. of cases
|
|||
---|---|---|---|
Disease | +/+ | -/- | Description |
B lymphoma | 2 | 10 | B220+, CD19+, CD43-, BCL-6+, surface IgG or IgM, diffuse large cell |
Malignant plasma cell dyscrasia | 0 | 2 | |
T lymphoma | 0 | 1 | |
Sarcoma | 0 | 2 | Angiosarcoma |
1 | Dendritic sarcoma | ||
Adenocarcinoma | 1 | 2 | |
Atypical lymphoid hyperplasia | 4 | 3 | B cell |
1 | 0 | Hematopoietic, nonlymphoid | |
Hemangioma | 0 | 2 | |
Hepatoma | 2 | 1 | |
No. of animals evaluated | 42 | 54 |