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The S727 residue is important for GRIM-19 binding to STAT3. (A) STAT3–/– cells were transfected with flag-tagged WT or mutant STAT3 constructs and an IP with GRIM-19-specific antibodies was performed as in Fig. 5. The same lysates were analyzed for the expression of STAT3 (B) and actin (C). WB, Western analysis.
