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. 2003 Jul 23;100(16):9354–9359. doi: 10.1073/pnas.1533295100

Fig. 7.

Fig. 7.

The reduced susceptibility of MIF-KO fibroblasts to ras-mediated transformation is p53-dependent (A) Focus formation by MIF-KO and WT fibroblasts coexpressing E1A and H-rasV12. (Upper) Representative morphology of a single colony induced by E1A and H-rasV12 in MIF-KO and WT MEFs (×10 magnification). (B) Western blot analysis of MIF-KO and WT MEFs infected with empty vector (V)- or E1A- and H-rasV12 (R)-containing retroviruses. (C) Growth curves of MIF-KO and WT fibroblasts coexpressing E1A and H-rasV12.(D) Focus formation by p53–/– and MIF–/–p53–/– DKO fibroblasts expressing H-RasV12, N-RasD12, or K-RasV12 mutants.