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. 2003 Jul 23;100(16):9354–9359. doi: 10.1073/pnas.1533295100

Fig. 8.

Fig. 8.

MIF-deficient mice exhibit delayed development of B[α]P-induced fibrosarcomas. (A) Tumor development by MIF-KO and WT BALB/c mice after treatment with DMBA as a tumor initiator and TPA as a promoter. *, significant with P < 0.05. (B) Tumor formation by C57BL/6 MIF-KO and WT mice after injection of B[α]P. (Left) Tumors developed by MIF-KO, and WT mice were excised in week 16 and weighed (P = 0.02). (Right) Mitotic index in B[α]P-induced fibrosarcomas from MIF-KO and WT mice (P = 0.003). (C) Histological examination of B[α]P-induced tumors in C57BL/6 MIF-KO and WT mice. Hematoxylin/eosin stain. Magnification: Upper, ×400; Lower, ×5. Arrowheads indicate cells undergoing mitoses.