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. 2003 Jul 18;100(16):9416–9421. doi: 10.1073/pnas.1533500100

Fig. 3.

Fig. 3.

High bone turnover in male ARKO mice and its partial prevention by an aromatizable androgen. (a) Two calcein-labeled mineralized fronts visualized by fluorescent micrography and bone formation parameters in the proximal tibia of 8-week-old male ARKO and WT littermate mice. Ob.S/BS, percentage of bone surface covered by cuboidal osteoblasts; MAR, mineral apposition rate. (b) Two calcein-labeled mineralized fronts and bone histomorphometric parameters in the midshaft of femora from 8-week-old male ARKO and WT littermate mice. ES/BS, percentage of eroded surface. (c) TRAP staining and bone resorption parameters in the proximal tibiae of 8-week-old male WT and ARKO mice. TRAP-positive osteoclasts on secondary spongiosa are stained red. Oc.S/BS, percentage of bone surface covered by mature osteoclasts; N.Oc/B.Pm, number of mature osteoclasts in 10 cm of bone perimeter. (d) Serum osteocalcin levels and urinary deoxypyridinoline levels of 8-week-old male ARKO and WT mice. (e) BMD values of femora from 8-week-old mice after orchidectomy (ORX) and hormone replacement. T, testosterone.