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Induction of NKG2D on CD4 T cells by IL-15 and TNF-α. (A and B) Exposure of normal PBL to IL-15 or TNF-α results in induced expression of NKG2D on gated CD3+CD4+ T cells. (C) This induction is markedly accelerated with CD4+NKG2D– T cells sorted from RA PBL. Data for TNF-α not shown. Numbers in dot plots indicate percentages of NKG2D positive and negative cells.
