Fig. 3.
Relationship among CB, c-Fos, plaque load, and Aβ levels. Brain sections and hippocampi were from hAPPFAD mice (black dots) and non-TG controls (empty dots). The square of correlation coefficients (R2) and P values refer to hAPPFAD mice only. (A) Relative levels of CB and c-Fos-IR granule cells in the dentate gyrus were strongly correlated in hAPPFAD mice but not in non-TG controls (n = 48–60 per genotype; age, 4–7 mo). (B) Levels of CB and c-Fos-IR granule cells did not correlate with hippocampal plaque load in hAPPFAD mice with early plaque formation (n = 39; age, 4–7 mo). (C) Hippocampal levels of Aβ1–42 and Aβ1–x (approximates total Aβ) were determined by ELISA as described (6, 29) in hAPPFAD mice (n = 18 females) over a wider range of ages (4–22 months; mean ± SD, 10.7 ± 6.7 mo).