Table 1. Classification of gene expression profiles induced by different drug treatments.

Compound	True class	CT pred	RF pred	Subclass
Amoxepine	AD	AD	AD	Tricyclic
Clomipramine	AD	AD	AD	Tricyclic
Desipramine	AD	OP	AD	Tricyclic
Doxepin	AD	AD	AD	Tricyclic
Imipramine	AD	AD	AD	Tricyclic
Maprotiline	AD	AD	AD	Tricyclic
Nortryptyline	AD	AD	AD	Tricyclic
Protriptyline	AD	AD	AD	Tricyclic
Trimipramine	AD	AD	AD	Tricyclic
Amitriptyline	AD	AD	AD	Tricyclic
Citalopram	AD	AD	AD	SSRI
Paroxetine	AD	AD	AD	SSRI
Sertraline	AD	AD	AD	SSRI
Fluoxetine	AD	AD	AD	SSRI
Fluvoxamine	AD	AD	AD	SSRI
Tranylcypromine	AD	AD	AD	MAOI
Phenelzine	AD	AP	AP	MAOI
Iproniazid	AD	AD	AP	MAOI
Trazadone	AD	AD	AD	Atypical
Buproprion	AD	AD	AD	Atypical
Chlorpromazine	AP	AP	AP	Classic
Trifluperazine	AP	AP	AP	Classic
Triflupromazine	AP	AP	AP	Classic
Pimozide	AP	AP	AP	Classic
Clozapine	AP	AD	AD	Atypical
Haloperidol	AP	AP	AP	Atypical
Risperidone	AP	AP	AP	Atypical
Loxapine	AP	AP	AD	Atypical
BW373U86	OP	OP	AD	δ OPR
Enkephalin	OP	AD	AD	δ OPR
U50488	OP	OP	OP	κ OPR
U62066	OP	OP	OP	κ OPR
Dynorphin A	OP	OP	AD	κ/μ OPR
DALDA	OP	OP	OP	μ OPR
DAMGO	OP	OP	OP	μ OPR
Endomorphin	OP	OP	OP	μ OPR
Percent ”correct”		88.9	83.3

True class, known therapeutic utility; AD, antidepressant; AP, antipsychotic; OP, opioid receptor agonist. CT pred and RF pred, classes predicted by those methods for the expression profiles elicited by the drugs listed on the left; boldface designations, predicted therapeutic classes different from the ”true” class. Subclass, the common pharmacological sub-classification; MAOI, monoamine oxidase inhibitor; δ, κ, μOPR, δ, κ, μ opioid receptor agonist, respectively