Table 1.

Checklist for identifying guidelines requiring adaptation

Factors influencing the applicability or transferability of guidelines across different settings	Response (positive answers increase the likelihood that recommendations should be flagged as requiring adaptation)
1. Is there important variation in need (prevalence, baseline risk or health status) that might lead to different decisions?	□ Yes □ Unclear □ No
2. Is there important variation in the availability of resources that might lead to different decisions?	□ Yes □ Unclear □ No
3. Is there important variation in costs (e.g. of drugs or human resources) that might lead to different decisions?	□ Yes □ Unclear □ No
4. Is there important variation in the presence of factors that could modify the expected effects (e.g. resistance patterns of microbiological pathogens), which might lead to different decisions?	□ Yes □ Unclear □ No
5. Is there important variation in the relative values of the main benefits and downsides that might lead to different decisions?	□ Yes □ Unclear □ No