Abstract
Mixed lymphocyte cultures were performed before renal transplantation in 36 patients, using the cells from the recipient and the prospective living donor. A highly significant correlation was found between the results of mixed leucocyte cultures and (a) the renal function at one year or two years; (b) the occurrence of early or late rejection crises. A good correlation was also found between the results of mixed cultures and leucocyte typing based on HL-A haplotypes (but not with conventional typing based on the number of antigenic differences). As applied to the selection of the donors for kidney transplantation, the mixed culture has the advantage of recognizing all the `good' cases, including the favourable cases of the HL-A semi-identical group; it will also select however a small number of poor cases. In contrast, the determination of HL-A haplotypes will select almost only `good' cases but will discard a significant number of cases which will eventually prove to be favourable.
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Selected References
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- Amos D. B., Bach F. H. Phenotypic expressions of the major histocompatibility locus in man (HL-A): leukocyte antigens and mixed leukocyte culture reactivity. J Exp Med. 1968 Oct 1;128(4):623–637. doi: 10.1084/jem.128.4.623. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bach F. H., Amos D. B. Hu-1: Major histocompatibility locus in man. Science. 1967 Jun 16;156(3781):1506–1508. doi: 10.1126/science.156.3781.1506. [DOI] [PubMed] [Google Scholar]
- Batchelor J. R., Joysey V. C. Influence of HL-A incompatibility on cadaveric renal transplantation. Lancet. 1969 Apr 19;1(7599):790–792. doi: 10.1016/s0140-6736(69)92062-5. [DOI] [PubMed] [Google Scholar]
- Dausset J., Walford R. L., Colombani J., Legrand L., Feingold N., Barge A., Rapaport F. T. The HL-A system sub-loci and their importance in transplantation. Transplant Proc. 1969 Mar;1(1):331–338. [PubMed] [Google Scholar]
- Debray-Sachs M., Dormont J., Bach J. F., Descamps B., Dausset J., Hamburger J. Leucocyte typing versus transformation in mixed lymphocyte culture. Lancet. 1968 Aug 10;2(7563):318–320. doi: 10.1016/s0140-6736(68)90529-1. [DOI] [PubMed] [Google Scholar]
- Huber H., Pastner D., Dittrich P., Braunsteiner H. In vitro reactivity of human lymphocytes in uraemia--a comparison with the impairment of delayed hypersensitivity. Clin Exp Immunol. 1969 Jul;5(1):75–82. [PMC free article] [PubMed] [Google Scholar]
- Kreis H., Leski M., Crosnier J., Hamburger J. The value of a genetic expression of leucocyte typing in renal transplantation. Clin Exp Immunol. 1970 Jun;6(6):815–819. [PMC free article] [PubMed] [Google Scholar]
- Morris P. J., Kincaid-Smith P., Ting A., Stocker J. W., Marshall V. C. Prospective leucocyte typing in cadaver renal transplantation. Lancet. 1968 Oct 12;2(7572):803–805. doi: 10.1016/s0140-6736(68)92458-6. [DOI] [PubMed] [Google Scholar]
- Pearce R., van Rood J. J., van Leeuwen A., van der Does J. A. Leukocyte typing and kidney transplantation in unrelated donor-recipient pairs. A study in patients of Drs. S. Peart, J.F.Mowbray, and G.R.J. Alexandre. Transplant Proc. 1969 Mar;1(1):372–375. [PubMed] [Google Scholar]
- Terasaki P. I., Vredevoe D. L., Mickey M. R. Serotyping for homotransplantation. X. Survival of 196 grafted kidneys subsequent to typing. Transplantation. 1967 Jul;5(4 Suppl):1057–1070. doi: 10.1097/00007890-196707001-00041. [DOI] [PubMed] [Google Scholar]