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. 1970 Dec;7(6):805–815.

Suppression of autoimmune disease in New Zealand mice associated with infection in malaria. II. NZB mice

B M Greenwood, A Voller
PMCID: PMC1712866  PMID: 4099670

Abstract

The onset of a positive Coombs test was significantly delayed in NZB mice infected with Plasmodium berghei at the age of 1 month. At the age of 12 months, twelve out of fourteen malaria-infected NZB mice had become Coombs positive but their reticulocyte counts and mean spleen weight were significantly lower than those of control NZB mice of the same age.

Malaria infection of young NZB mice was associated with a significant increase in mean 24-hr urine protein excretion which fell gradually over the next 6 months. A secondary rise in urine protein excretion then occurred and at 12 months several malaria-infected NZB mice had severe renal disease.

No increased incidence of malignant disease was observed in NZB mice infected with malaria.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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