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. 1971 May;8(5):723–739.

Rheumatoid serumfactor in populations in the U.K. I. Lung disease and rheumatoid serum factor

J S Lawrence, G B Locke, J Ball
PMCID: PMC1712983  PMID: 5104047

Abstract

In population samples in England and Wales a greater frequency of positive sheep cell agglutination tests has been found in Leigh and the Rhondda than in Wensleydale, the Vale of Glamorgan or Watford.

The urban population of Leigh had more X-ray evidence of lung pathology than the rural population of Wensleydale. Seropositive persons in both the urban populations of Leigh and the Rhondda and the rural populations of Wensleydale and Glamorgan had more X-ray evidence of lung pathology than seronegative individuals, the difference being significant for healed tuberculosis of the lungs, thickened basal pleura and increased basal vascular markings. The association between the first two and rheumatoid factor was equally present in those with and without arthritis but in the third it was limited to those with arthritis. A history of bronchitis was no more common in persons with a positive sheep cell test than in those with a negative test and the indirect maximum breathing capacity showed no significant relationship to rheumatoid factor titre.

No association was found between cigarette smoking and the sheep cell titre.

It is concluded that parenchymal lung and pleural disease may act as a stimulus to the production of rheumatoid serum factor and that this stimulus is independent of the presence or absence of arthritis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ASKONAS B. A., HUMPHREY J. H. Formation of antibody by isolated perfused lungs of immunized rabbits: the use of [14C]amino acids to study the dynamics of antibody secretion. Biochem J. 1958 Oct;70(2):212–222. doi: 10.1042/bj0700212. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ansell B. M., Lawrence J. S. Fluoridation and the rheumatic diseases. A comparison of rheumatism in Watford and Leigh. Ann Rheum Dis. 1966 Jan;25(1):67–75. [PMC free article] [PubMed] [Google Scholar]
  3. BALL J. Differential agglutination test in rheumatoid arthritis complicated by pneumoconiosis. Ann Rheum Dis. 1955 Jun;14(2):159–161. doi: 10.1136/ard.14.2.159. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BALL J., LAWRENCE J. S. Epidemiology of the sheep cell agglutination test. Ann Rheum Dis. 1961 Sep;20:235–243. doi: 10.1136/ard.20.3.235. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. BALL J., LAWRENCE J. S. THE RELATIONSHIP OF RHEUMATOID SERUM FACTOR TO RHEUMATOID ARTHRITIS: A 5-YEAR FOLLOW UP OF A POPULATION SAMPLE. Ann Rheum Dis. 1963 Sep;22:311–318. doi: 10.1136/ard.22.5.311. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bonomo L., Gillardi U., Tursi A. Anti-gamma-globulin and antinuclear factors in chronic bronchitis. Relation to disease course and hyperglobulinemia. Am J Clin Pathol. 1966 Mar;45(3):313–322. doi: 10.1093/ajcp/45.3.313. [DOI] [PubMed] [Google Scholar]
  7. Bremner J. M. Rheumatic Complaints in a Rural Population. Ann Rheum Dis. 1961 Jun;20(2):149–160. doi: 10.1136/ard.20.2.149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. CAPLAN A. Certain unusual radiological appearances in the chest of coal-miners suffering from rheumatoid arthritis. Thorax. 1953 Mar;8(1):29–37. doi: 10.1136/thx.8.1.29. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. CHRISTIE G. S. Pulmonary lesions in rheumatoid arthritis. Australas Ann Med. 1954 Feb;3(1):49–58. doi: 10.1111/imj.1954.3.1.49. [DOI] [PubMed] [Google Scholar]
  10. Cobb S., Hall W. Newly identified cluster of diseases. Rheumatoid arthritis, peptic ulcer, and tuberculosis. JAMA. 1965 Sep 27;193(13):1077–1079. [PubMed] [Google Scholar]
  11. DIXON A. S., BALL J. Honeycomb lung and chronic rheumatoid arthritis; a case report. Ann Rheum Dis. 1957 Jun;16(2):241–245. doi: 10.1136/ard.16.2.241. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. DOLL R., HILL A. B. Smoking and carcinoma of the lung; preliminary report. Br Med J. 1950 Sep 30;2(4682):739–748. doi: 10.1136/bmj.2.4682.739. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. DRESNER E., TROMBLY P. The latex-fixation reaction in nonrheumatic diseases. N Engl J Med. 1959 Nov 12;261:981–988. doi: 10.1056/NEJM195911122612001. [DOI] [PubMed] [Google Scholar]
  14. Davies D., Lindars D. C. Rheumatoid pneumoconiosis. A clinical study. Am Rev Respir Dis. 1968 Apr;97(4):617–629. doi: 10.1164/arrd.1968.97.4.617. [DOI] [PubMed] [Google Scholar]
  15. GORRINGE J. A. Serum protein changes in Caplan's syndrome. Ann Rheum Dis. 1962 Jun;21:135–153. doi: 10.1136/ard.21.2.135. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. HEIMER R., SCHWARTZ E. R. Isolation of rheumatoid factors. Arthritis Rheum. 1961 Apr;4:153–160. doi: 10.1002/art.1780040204. [DOI] [PubMed] [Google Scholar]
  17. HORLER A. R., THOMPSON M. The pleural and pulmonary complications of rheumatoid arthritis. Ann Intern Med. 1959 Dec;51:1179–1203. doi: 10.7326/0003-4819-51-6-1179. [DOI] [PubMed] [Google Scholar]
  18. HOUSTON J., LAWRENCE J. S. The blood sedimentation rate and fractional plasma viscosity in pulmonary tuberculosis. Br J Tuberc Dis Chest. 1955 Apr;49(2):119–128. doi: 10.1016/s0366-0869(55)80090-1. [DOI] [PubMed] [Google Scholar]
  19. Hannestad K. Rheumatoid factors reacting with autologous native gamma-G-globulin and joint fluid gamma-G aggregates. Clin Exp Immunol. 1968 Sep;3(7):671–690. [PMC free article] [PubMed] [Google Scholar]
  20. Kellgren J. H. Epidemiology of rheumatoid arthritis. Arthritis Rheum. 1966 Oct;9(5):658–674. doi: 10.1002/art.1780090503. [DOI] [PubMed] [Google Scholar]
  21. LAWRENCE J. S., BENNETT P. H. Benign polyarthritis. Ann Rheum Dis. 1960 Mar;19:20–30. doi: 10.1136/ard.19.1.20. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. LOCKE G. B. Rheumatoid lung. Clin Radiol. 1963 Jan;14:43–53. doi: 10.1016/s0009-9260(63)80009-4. [DOI] [PubMed] [Google Scholar]
  23. Lawrence J. S., Behrend T., Bennett P. H., Bremner J. M., Burch T. A., Gofton J., O'Brien W., Robinson H. Geographical studies on rheumatoid arthritis. Ann Rheum Dis. 1966 Sep;25(5):425–432. doi: 10.1136/ard.25.5.425. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Lindars D. C., Davies D. Rheumatoid pneumoconiosis: a study in colliery populations in the East Midlands coalfield. Thorax. 1967 Nov;22(6):525–532. doi: 10.1136/thx.22.6.525. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. MIALL W. E., BALL J., KELLGREN J. H. Prevalence of rheumatoid arthritis in urban and rural populations in South Wales. Ann Rheum Dis. 1958 Sep;17(3):263–272. doi: 10.1136/ard.17.3.263. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. MIALL W. E., CAPLAN A., COCHRANE A. L., KILPATRICK G. S., OLDHAM P. D. An epidemiological study of rheumatoid arthritis associated with characteristic chest x-ray appearances in coal-workers. Br Med J. 1953 Dec 5;2(4848):1231–1236. doi: 10.1136/bmj.2.4848.1231. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. MIALL W. E. Rheumatoid arthritis in males; an epidemiological study of a Welsh mining community. Ann Rheum Dis. 1955 Jun;14(2):150–158. doi: 10.1136/ard.14.2.150. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. PATTERSON C. D., HARVILLE W. E., PIERCE J. A. RHEUMATOID LUNG DISEASE. Ann Intern Med. 1965 Apr;62:685–697. doi: 10.7326/0003-4819-62-4-685. [DOI] [PubMed] [Google Scholar]
  29. PEARSON C. M. EXPERIMENTAL MODELS IN RHEUMATOID DISEASE. Arthritis Rheum. 1964 Feb;7:80–86. doi: 10.1002/art.1780070111. [DOI] [PubMed] [Google Scholar]
  30. RHEINS M. S., MCCOY F. W., BURRELL R. G., BUEHLER E. V. A modification of the latex-fixation test for the study of rheumatoid arthritis. J Lab Clin Med. 1957 Jul;50(1):113–118. [PubMed] [Google Scholar]
  31. Roujeau J., Amouroux J. Le poumon rhumatoïde. Etude anatomique. Rev Tuberc Pneumol (Paris) 1968 Jul-Aug;32(5):717–728. [PubMed] [Google Scholar]
  32. SINGER J. M., PLOTZ C. M., PERLATA F. M., LYONS H. C. The presence of anti-gamma globulin factors in sera of patients with active pulmonary tuberculosis. Ann Intern Med. 1962 Apr;56:545–552. doi: 10.7326/0003-4819-56-4-545. [DOI] [PubMed] [Google Scholar]
  33. SPIERA H. EXCRETION OF A TRYPTOPHAN METABOLITE IN RHEUMATOID ARTHRITIS. Arthritis Rheum. 1963 Aug;6:364–371. doi: 10.1002/art.1780060407. [DOI] [PubMed] [Google Scholar]
  34. Scadding J. G. The lungs in rheumatoid arthritis. Proc R Soc Med. 1969 Mar 3;62(3):227–238. [PMC free article] [PubMed] [Google Scholar]
  35. Stack B. H., Grant I. W. Rheumatoid interstitial lung disease. Br J Dis Chest. 1965 Oct;59(4):202–211. doi: 10.1016/s0007-0971(65)80050-x. [DOI] [PubMed] [Google Scholar]
  36. Valkenburg H. A., Ball J., Burch T. A., Bennett P. H., Lawrence J. S. Rheumatoid factors in a rural population. Ann Rheum Dis. 1966 Nov;25(6):497–508. doi: 10.1136/ard.25.6.497. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Verhaeghe A., Delcambre B. Polyarthrite rhumatoïde et silicose pulmonaire. Rev Rhum Mal Osteoartic. 1967 Dec;34(12):746–755. [PubMed] [Google Scholar]
  38. WILLIAMS R. C., Jr, KUNKEL H. G. SEPARATION OF RHEUMATOID FACTORS OF DIFFERENT SPECIFICITIES USING COLUMNS CONJUGATED WITH GAMMA-GLOBULIN. Arthritis Rheum. 1963 Dec;6:665–675. doi: 10.1002/art.1780060602. [DOI] [PubMed] [Google Scholar]
  39. Walker W. C., Wright V. Diffuse interstitial pulmonary fibrosis and rheumatoid arthritis. Ann Rheum Dis. 1969 May;28(3):252–259. doi: 10.1136/ard.28.3.252. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Walker W. C., Wright V. Rheumatoid pleuritis. Ann Rheum Dis. 1967 Nov;26(6):467–474. doi: 10.1136/ard.26.6.467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. White R. G. Antigens and adjuvants. Proc R Soc Med. 1968 Jan;61(1):1–6. [PMC free article] [PubMed] [Google Scholar]

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