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Antithetic regulation of PLC-β1 expression by βAR activity in airway smooth muscle cells. (a) PLC-β1 was decreased approximately 60% in βAR–/– cells (P < 0.001) and (b) increased twofold in β2AR-OE cells (P = 0.01), compared with their wild-type littermates. In contrast, expression levels of Gαq and Gαs were not different.
