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A schematic of two mRNA variants derived from alternative splicing of a primary transcript. In situation i, exon 2 is recognized whereas exon 3 is not and is read as being part of a large intron. In contrast, the reverse is true for situation ii. In many instances, alternative splicing is tightly regulated in cell type–specific fashion (27). An, refers to the polyA tail at the 3′ end of mRNAs.
