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. 1989 Feb;44(2):264–269.

Androgen receptor locus on the human X chromosome: regional localization to Xq11-12 and description of a DNA polymorphism.

C J Brown 1, S J Goss 1, D B Lubahn 1, D R Joseph 1, E M Wilson 1, F S French 1, H F Willard 1
PMCID: PMC1715398  PMID: 2563196

Abstract

The gene for the androgen receptor, mutations at which cause the X-linked androgen insensitivity syndrome, has been localized to the q11----q12 region of the human X chromosome by analysis, using a cloned cDNA for the androgen receptor, of somatic cell hybrid panels segregating portions of the X chromosome. A moderate-frequency HindIII RFLP has been found which should be useful in genetic linkage analysis of the various inherited forms of androgen insensitivity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arveiler B., Oberlé I., Mandel J. L. Genetic mapping of nine DNA markers in the q11----q22 region of the human X chromosome. Genomics. 1987 Sep;1(1):60–66. doi: 10.1016/0888-7543(87)90105-4. [DOI] [PubMed] [Google Scholar]
  2. Botstein D., White R. L., Skolnick M., Davis R. W. Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet. 1980 May;32(3):314–331. [PMC free article] [PubMed] [Google Scholar]
  3. Brown T. R., Lubahn D. B., Wilson E. M., Joseph D. R., French F. S., Migeon C. J. Deletion of the steroid-binding domain of the human androgen receptor gene in one family with complete androgen insensitivity syndrome: evidence for further genetic heterogeneity in this syndrome. Proc Natl Acad Sci U S A. 1988 Nov;85(21):8151–8155. doi: 10.1073/pnas.85.21.8151. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Buck D. W., Goss S. J., Bodmer W. F. Regional mapping of the X-linked gene for a human cell surface antigen, SA-X. Cytogenet Cell Genet. 1976;16(1-5):99–100. doi: 10.1159/000130563. [DOI] [PubMed] [Google Scholar]
  5. Chang C. S., Kokontis J., Liao S. T. Molecular cloning of human and rat complementary DNA encoding androgen receptors. Science. 1988 Apr 15;240(4850):324–326. doi: 10.1126/science.3353726. [DOI] [PubMed] [Google Scholar]
  6. Davisson M. T. X-linked genetic homologies between mouse and man. Genomics. 1987 Nov;1(3):213–227. doi: 10.1016/0888-7543(87)90047-4. [DOI] [PubMed] [Google Scholar]
  7. Fichman K. R., Migeon B. R., Migeon C. J. Genetic disorders of male sexual differentiation. Adv Hum Genet. 1980;10:333-77, 387. doi: 10.1007/978-1-4615-8288-5_5. [DOI] [PubMed] [Google Scholar]
  8. Goss S. J., Harris H. New method for mapping genes in human chromosomes. Nature. 1975 Jun 26;255(5511):680–684. doi: 10.1038/255680a0. [DOI] [PubMed] [Google Scholar]
  9. Lubahn D. B., Joseph D. R., Sullivan P. M., Willard H. F., French F. S., Wilson E. M. Cloning of human androgen receptor complementary DNA and localization to the X chromosome. Science. 1988 Apr 15;240(4850):327–330. doi: 10.1126/science.3353727. [DOI] [PubMed] [Google Scholar]
  10. Lyon M. F., Hawkes S. G. X-linked gene for testicular feminization in the mouse. Nature. 1970 Sep 19;227(5264):1217–1219. doi: 10.1038/2271217a0. [DOI] [PubMed] [Google Scholar]
  11. Mahtani M. M., Willard H. F. A primary genetic map of the pericentromeric region of the human X chromosome. Genomics. 1988 May;2(4):294–301. doi: 10.1016/0888-7543(88)90017-1. [DOI] [PubMed] [Google Scholar]
  12. Meyer W. J., 3rd, Migeon B. R., Migeon C. J. Locus on human X chromosome for dihydrotestosterone receptor and androgen insensitivity. Proc Natl Acad Sci U S A. 1975 Apr;72(4):1469–1472. doi: 10.1073/pnas.72.4.1469. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Migeon B. R., Brown T. R., Axelman J., Migeon C. J. Studies of the locus for androgen receptor: localization on the human X chromosome and evidence for homology with the Tfm locus in the mouse. Proc Natl Acad Sci U S A. 1981 Oct;78(10):6339–6343. doi: 10.1073/pnas.78.10.6339. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Pinsky L., Kaufman M. Genetics of steroid receptors and their disorders. Adv Hum Genet. 1987;16:299–472. doi: 10.1007/978-1-4757-0620-8_5. [DOI] [PubMed] [Google Scholar]
  15. Trapman J., Klaassen P., Kuiper G. G., van der Korput J. A., Faber P. W., van Rooij H. C., Geurts van Kessel A., Voorhorst M. M., Mulder E., Brinkmann A. O. Cloning, structure and expression of a cDNA encoding the human androgen receptor. Biochem Biophys Res Commun. 1988 May 31;153(1):241–248. doi: 10.1016/s0006-291x(88)81214-2. [DOI] [PubMed] [Google Scholar]
  16. Wieacker P., Griffin J. E., Wienker T., Lopez J. M., Wilson J. D., Breckwoldt M. Linkage analysis with RFLPs in families with androgen resistance syndromes: evidence for close linkage between the androgen receptor locus and the DXS1 segment. Hum Genet. 1987 Jul;76(3):248–252. doi: 10.1007/BF00283617. [DOI] [PubMed] [Google Scholar]
  17. Willard H. F., Goss S. J., Holmes M. T., Munroe D. L. Regional localization of the phosphoglycerate kinase gene and pseudogene on the human X chromosome and assignment of a related DNA sequence to chromosome 19. Hum Genet. 1985;71(2):138–143. doi: 10.1007/BF00283369. [DOI] [PubMed] [Google Scholar]
  18. Willard H. F., Riordan J. R. Assignment of the gene for myelin proteolipid protein to the X chromosome: implications for X-linked myelin disorders. Science. 1985 Nov 22;230(4728):940–942. doi: 10.1126/science.3840606. [DOI] [PubMed] [Google Scholar]
  19. Willard H. F., Smith K. D., Sutherland J. Isolation and characterization of a major tandem repeat family from the human X chromosome. Nucleic Acids Res. 1983 Apr 11;11(7):2017–2033. doi: 10.1093/nar/11.7.2017. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Zonana J., Clarke A., Sarfarazi M., Thomas N. S., Roberts K., Marymee K., Harper P. S. X-linked hypohidrotic ectodermal dysplasia: localization within the region Xq11-21.1 by linkage analysis and implications for carrier detection and prenatal diagnosis. Am J Hum Genet. 1988 Jul;43(1):75–85. [PMC free article] [PubMed] [Google Scholar]

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