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. 1990 Feb;34(2):368–370. doi: 10.1128/aac.34.2.368

In vitro activities of tosufloxacin, temafloxacin, and A-56620 against pathogens of diarrhea.

J P Bryan 1, C Waters 1, J Sheffield 1, R E Krieg 1, P L Perine 1, K Wagner 1
PMCID: PMC171591  PMID: 2327784

Abstract

Tosufloxacin (A-60969 HCl), a new quinolone with broad activity against gram-positive and anaerobic organisms, was compared in vitro with other quinolones against bacterial pathogens of diarrhea. Tosufloxacin was the most active agent against Salmonella spp., Shigella spp., Campylobacter spp., Aeromonas hydrophila, and Vibrio spp. Temafloxacin (A-62254) also demonstrated good activity against these organisms.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blaser M. J., Wells J. G., Feldman R. A., Pollard R. A., Allen J. R. Campylobacter enteritis in the United States. A multicenter study. Ann Intern Med. 1983 Mar;98(3):360–365. doi: 10.7326/0003-4819-98-3-360. [DOI] [PubMed] [Google Scholar]
  2. Bryan J. P., Rocha H., Scheld W. M. Problems in salmonellosis: rationale for clinical trials with newer beta-lactam agents and quinolones. Rev Infect Dis. 1986 Mar-Apr;8(2):189–207. doi: 10.1093/clinids/8.2.189. [DOI] [PubMed] [Google Scholar]
  3. Ericsson C. D., Johnson P. C., Dupont H. L., Morgan D. R., Bitsura J. A., de la Cabada F. J. Ciprofloxacin or trimethoprim-sulfamethoxazole as initial therapy for travelers' diarrhea. A placebo-controlled, randomized trial. Ann Intern Med. 1987 Feb;106(2):216–220. doi: 10.7326/0003-4819-106-2-216. [DOI] [PubMed] [Google Scholar]
  4. Espinoza A. M., Chin N. X., Novelli A., Neu H. C. Comparative in vitro activity of a new fluorinated 4-quinolone, T-3262 (A-60969). Antimicrob Agents Chemother. 1988 May;32(5):663–670. doi: 10.1128/aac.32.5.663. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ferreccio C., Morris J. G., Jr, Valdivieso C., Prenzel I., Sotomayor V., Drusano G. L., Levine M. M. Efficacy of ciprofloxacin in the treatment of chronic typhoid carriers. J Infect Dis. 1988 Jun;157(6):1235–1239. doi: 10.1093/infdis/157.6.1235. [DOI] [PubMed] [Google Scholar]
  6. Fujimaki K., Noumi T., Saikawa I., Inoue M., Mitsuhashi S. In vitro and in vivo antibacterial activities of T-3262, a new fluoroquinolone. Antimicrob Agents Chemother. 1988 Jun;32(6):827–833. doi: 10.1128/aac.32.6.827. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Goossens H., De Mol P., Coignau H., Levy J., Grados O., Ghysels G., Innocent H., Butzler J. P. Comparative in vitro activities of aztreonam, ciprofloxacin, norfloxacin, ofloxacin, HR 810 (a new cephalosporin), RU28965 (a new macrolide), and other agents against enteropathogens. Antimicrob Agents Chemother. 1985 Mar;27(3):388–392. doi: 10.1128/aac.27.3.388. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Gotuzzo E., Guerra J. G., Benavente L., Palomino J. C., Carrillo C., Lopera J., Delgado F., Nalin D. R., Sabbaj J. Use of norfloxacin to treat chronic typhoid carriers. J Infect Dis. 1988 Jun;157(6):1221–1225. doi: 10.1093/infdis/157.6.1221. [DOI] [PubMed] [Google Scholar]
  9. Keusch G. T. Antimicrobial therapy for enteric infections and typhoid fever: state of the art. Rev Infect Dis. 1988 Jan-Feb;10 (Suppl 1):S199–S205. doi: 10.1093/clinids/10.supplement_1.s199. [DOI] [PubMed] [Google Scholar]
  10. Pichler H. E., Diridl G., Stickler K., Wolf D. Clinical efficacy of ciprofloxacin compared with placebo in bacterial diarrhea. Am J Med. 1987 Apr 27;82(4A):329–332. [PubMed] [Google Scholar]
  11. Ramirez C. A., Bran J. L., Mejia C. R., Garcia J. F. Open, prospective study of the clinical efficacy of ciprofloxacin. Antimicrob Agents Chemother. 1985 Jul;28(1):128–132. doi: 10.1128/aac.28.1.128. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Segreti J., Nelson J. A., Goodman L. J., Kaplan R. L., Trenholme G. M. In vitro activities of lomefloxacin and temafloxacin against pathogens causing diarrhea. Antimicrob Agents Chemother. 1989 Aug;33(8):1385–1387. doi: 10.1128/aac.33.8.1385. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Taylor D. N., Blaser M. J., Echeverria P., Pitarangsi C., Bodhidatta L., Wang W. L. Erythromycin-resistant Campylobacter infections in Thailand. Antimicrob Agents Chemother. 1987 Mar;31(3):438–442. doi: 10.1128/aac.31.3.438. [DOI] [PMC free article] [PubMed] [Google Scholar]

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