Table 2.
Genes Upregulated in E2-Treated LuCaP 35V versus Untreated LuCaP 35V.
| Human Genome Organization Gene | Name | GenBank | Entrez Gene | Average Fold Δ | Gene List | |
| Metabolism | ||||||
| Carbohydrate | ||||||
| Lyzs | Lysozyme (Mus musculus) | M21050 | 17105 | 2.9 | ||
| SIAT1 | Sialyltransferase 1 | NM_173217 | 6480 | 2.7 | ||
| EXT1 | Exostoses 1 | BQ021387 | 2131 | 1.8 | ||
| Lipid/sterol | ||||||
| UGT2B15 | UDP glycosyltransferase 2 family, polypeptide B15 | AF180322 | 7366 | 3.7 | ||
| SORL1 | Sortilin-related receptor, L (DLR class) A repeats-containing | AK096577 | 6653 | 2.4 | ||
| PSAP | Prosaposin | CR617297 | 5660 | 1.9 | ||
| APOE | Apolipoprotein E | BG715607 | 348 | 1.8 | ||
| CLN2 | Ceroid lipofuscinosis, neuronal 2, late infantile | AF017456 | 1200 | 1.8 | ||
| Protein | ||||||
| FOLH1 | Folate hydrolase (prostate-specific membrane antigen) 1 | BC025672 | 2346 | 3.6 | ||
| SQSTM1 | Sequestosome 1 | BQ220165 | 8878 | 1.8 | ||
| DDC | Dopa decarboxylase | CA488364 | 1644 | 1.8 | ||
| MAOA | Monoamine oxidase A | NM_000240 | 4128 | 1.5 | ||
| Other | ||||||
| SOD2 | Superoxide dismutase 2, mitochondrial | BU527631 | 6648 | 1.9 | ||
| VKORC1 | Vitamin K epoxide reductase complex, subunit 1 | NM_024006 | 79001 | 1.7 | ||
| TBC1D14 | TBC1 domain family, member 14 | AL833868 | 57533 | 1.5 | ||
| Immune response | ||||||
| CD74 | CD74 antigen | CA437013 | 972 | 5.1 | ||
| HLA DRA | MHC, class II, DR α | BG757515 | 3122 | 3.4 | ||
| HLA F | MHC, class I, F | AK096962 | 3134 | 3.0 | ||
| LGALS3BP | Lectin, galactoside-binding, soluble, 3-binding protein | BQ883924 | 3959 | 2.6 | ||
| HLA DQB1 | MHC, class II, DQ β1 | L34104 | 3119 | 2.5 | ||
| HLA C | MHC, class I, C | X67818 | 3107 | 2.4 | ||
| HLA B | MHC, class I, B | AK124160 | 3106 | 2.3 | IFN | |
| HLA A | MHC, class I, A | AK027084 | 3105 | 2.2 | IFN | |
| IFITM3 | IFN-induced transmembrane protein 3 | BQ441207 | 10410 | 2.1 | ||
| BST2 | Bone marrow stromal cell antigen 2 | BQ053580 | 684 | 2.0 | IFN | |
| β2M | β2-Microglobulin | BM453762 | 567 | 1.9 | AR, IFN | |
| CD59 | CD59 antigen p18–20 | BM550387 | 966 | 1.8 | ||
| IFIT1 | IFN-induced protein with tetratricopeptide repeats 1 | BI670242 | 3434 | 1.8 | IFN | |
| IRF1 | IFN-regulatory factor 1 | CR594837 | 3659 | 1.8 | IFN | |
| IFI27 | IFNα-inducible protein 27 | BM998410 | 3429 | 1.5 | IFN | |
| Proliferation/differentiation/apoptosis | ||||||
| NDRG4 | NDRG family member 4 | AB021172 | 65009 | 2.8 | ||
| BCCIP | BRCA2 and CDKN1A-interacting protein | BQ421346 | 56647 | 1.7 | ||
| BIRC3 | Baculoviral IAP repeat-containing 3 | BC037420 | 330 | 1.7 | AR | |
| TMBIM1 | Transmembrane BAX inhibitor motif-containing 1 | AK130380 | 64114 | 1.6 | ||
| AGR2 | Anterior gradient 2 homolog | BQ685832 | 10551 | 1.6 | AR | |
| UNC13B | Unc-13 homolog B | NM_006377 | 10497 | 1.6 | ||
| TM4SF13 | Transmembrane 4 superfamily member 13 | AK093487 | 27075 | 1.6 | ||
| NPM1 | Nucleophosmin | CN404150 | 4869 | 1.6 | ||
| NDRG1 | N-myc downstream-regulated gene 1 | CR600627 | 10397 | 1.5 | AR | |
| KIAA0971 | KIAA0971 protein | CD671614 | 22868 | 1.5 | ||
| Signal transduction | ||||||
| HSPA1A | Heat shock 70 kDa protein 1A | CR605852 | 3303 | 7.3 | ||
| IFITM1 | IFN-induced transmembrane protein 1 | BQ219055 | 8519 | 2.8 | IFN | |
| LY6E | Lymphocyte antigen 6 complex, locus E | U42376 | 4061 | 2.2 | ||
| STAT1 | Signal transducer and activator of transcription 1, 91 kDa | BG678000 | 6772 | 1.9 | IFN | |
| ARHGAP5 | Rho GTPase-activating protein 5 | BG260763 | 394 | 1.8 | ||
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | U77413 | 8473 | 1.7 | ||
| RALGPS1A | Ral guanine nucleotide exchange factor RalGPS1A | AB002349 | 9649 | 1.6 | ||
| FKBP4 | FK506-binding protein 4, 59 kDa | CD613711 | 2288 | 1.5 | ||
| SH3KBP1 | SH3 domain kinase-binding protein 1 | AY423734 | 30011 | 1.5 | ||
| NUDT4 | Nudix-type motif 4 | NM_019094 | 11163 | 1.5 | ||
| Structure/adhesion/motility | ||||||
| MYLK | Myosin, light polypeptide kinase | BC062755 | 4638 | 3.9 | AR | |
| MYH3 | Myosin, heavy polypeptide 3, skeletal muscle, embryonic | CK824450 | 4621 | 1.8 | ||
| SPARC | Secreted protein, acidic, cysteine-rich (osteonectin) | AL547671 | 6678 | 1.8 | ||
| INA | Internexin neuronal intermediate filament protein, α | CR591335 | 9118 | 1.6 | ||
| CLDN4 | Claudin 4 | BC000671 | 1364 | 1.5 | ||
| LAMB2 | Laminin, β2 | AI754927 | 3913 | 1.5 | ||
| Transcription regulation | ||||||
| ID1 | Inhibitor of DNA-binding 1, dominant-negative helix-loop-helix protein | BM973065 | 3397 | 2.7 | ||
| HIST1H2AC | Histone 1, H2ac | BC050602 | 8334 | 2.3 | ||
| PMF1 | Polyamine-modulated factor 1 | BC050735 | 11243 | 2.0 | ||
| NONO | Non-POU domain-containing, octamer binding | BG171743 | 4841 | 1.9 | ||
| ZNFX1 | Zinc finger, NFX1 type-containing 1 | AB037825 | 57169 | 1.7 | ||
| NFAT5 | Nuclear factor of activated T-cells 5, tonicity-responsive | NM_006599 | 10725 | 1.7 | ||
| NOLC1 | Nucleolar and coiled-body phosphoprotein 1 | BE908347 | 9221 | 1.7 | ||
| TRIM22 | Tripartite motif-containing 22 | AW080955 | 10346 | 1.7 | AR, IFN | |
| GPBP1 | GC-rich promoter-binding protein 1 | AL161991 | 65056 | 1.6 | ||
| ADAR | Adenosine deaminase, RNA-specific | U18121 | 103 | 1.5 | IFN | |
| Translation-protein synthesis | ||||||
| HSP90AA2 | Heat shock protein 90 kDa α, class A member 2 | BC001695 | 3324 | 2.1 | ||
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | BC002352 | 3337 | 1.9 | ||
| GOLPH4 | Golgi phosphoprotein 4 | AA447271 | 27333 | 1.8 | ||
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | BQ221194 | 3301 | 1.8 | ||
| EIF4A2 | Eukaryotic translation initiation factor 4A, isoform 2 | BT009860 | 1974 | 1.7 | ||
| RPL23AP7 | Ribosomal protein L23a pseudogene 7 | X92108 | 118433 | 1.6 | ||
| UBC | Ubiquitin C | AK129749 | 7316 | 1.5 | AR | |
| Transport | ||||||
| SELENBP1 | Selenium-binding protein 1 | BC009084 | 8991 | 2.9 | ||
| APBA2 | Amyloid β (A4) precursor protein-binding, family A, member 2 | BC082986 | 321 | 2.6 | ||
| FLJ39822 | Hypothetical protein FLJ39822 | CA390853 | 151258 | 2.0 | ||
| SLC12A2 | Solute carrier family 12, member 2 | AF439152 | 6558 | 2.0 | ||
| FLJ39822 | Hypothetical protein FLJ39822 | AC019197 | 151258 | 1.9 | ||
| C6orf29 | Chromosome 6 open reading frame 29 | AY358457 | 80736 | 1.9 | ||
| ATP1B1 | ATPase, Na+/K+ transporting, β1 polypeptide | NM_001677 | 481 | 1.7 | ||
| ATP6V1A | ATPase, H+ transporting, lysosomal 70 kDa, V1 subunit A | BC012169 | 523 | 1.7 | ||
| FLJ10618 | Hypothetical protein FLJ10618 | AL049246 | 55186 | 1.5 | ||
| NPC2 | Niemann-Pick disease, type C2 | CR608935 | 10577 | 1.5 | ||
| NAPA | N-ethylmaleimide-sensitive factor attachment protein, α | BC007432 | 8775 | 1.5 | ||
| ATP6AP2 | ATPase, H+ transporting, lysosomal accessory protein 2 | BI491181 | 10159 | 1.5 | ||
| SLC25A26 | Solute carrier family 25, member 26 | AJ580932 | 115286 | 1.5 | ||
| Other/unknown | ||||||
| MUC13 | Mucin 13, epithelial transmembrane | AK000070 | 56667 | 3.9 | ||
| SAMD9L | Sterile α motif domain-containing 9-like | BC038974 | 219285 | 3.8 | ||
| Transcribed locus | CD103928 | 2.8 | ||||
| Transcribed locus, strongly similar to XP_496055.1 (predicted: similar to p40) | AW452111 | 2.3 | ||||
| C1orf43 | Chromosome 1 open reading frame 43 | BQ900746 | 25912 | 1.9 | ||
| C1orf80 | Chromosome 1 open reading frame 80 | BC015535 | 64853 | 1.8 | ||
| SERINC3 | Serine incorporator 3 | BI518460 | 10955 | 1.8 | ||
| FAM73A | Family with sequence similarity 73, member A | AU131144 | 374986 | 1.6 | ||
| ITM2B | Integral membrane protein 2B | CR745752 | 9445 | 1.6 | ||