Table 3.
Genes Downregulated in E2-Treated LuCaP 35V Versus Untreated LuCaP 35V.
| Human Genome Organization Gene | Name | GenBank | Entrez Gene | Average Fold Δ | Gene List |
| Metabolism | |||||
| Carbohydrate | |||||
| UGDH | UDP glucose dehydrogenase | BC022781 | 7358 | -2.0 | |
| GALNT7 | UDP N-acetyl-α-d-galactosamine | BM976847 | 51809 | -1.8 | |
| GPI | Glucose phosphate isomerase | AI124792 | 2821 | -1.8 | |
| RPN1 | Ribophorin I | CD644128 | 6184 | -1.8 | AR |
| SORD | Sorbitol dehydrogenase | BC025295 | 6652 | -1.6 | AR |
| GRHPR | Glyoxylate reductase/hydroxypyruvate reductase | BE728720 | 9380 | -1.5 | |
| ACLY | ATP citrate lyase | BI869432 | 47 | -1.5 | |
| Lipid/sterol | |||||
| RODH | 3-Hydroxysteroid epimerase | AF223225 | 8630 | -9.5 | |
| FACL3 | Fatty acid-coenzyme A ligase, long-chain 3 | AK023191 | 2181 | -3.0 | |
| TMEPAI | Transmembrane, prostate androgen-induced RNA | NM_199170 | 56937 | -2.6 | AR |
| PPAP2A | Phosphatidic acid phosphatase type 2A | CR617429 | 8611 | -2.5 | |
| EBP | Emopamil-binding protein (sterol isomerase) | CN395741 | 10682 | -2.2 | AR |
| DHCR24 | 24-Dehydrocholesterol reductase | BC011669 | 1718 | -2.1 | AR |
| PIGF | Phosphatidylinositol glycan, class F | BQ006858 | 5281 | -2.1 | |
| CERK | Ceramide kinase | NM_182661 | 64781 | -1.5 | |
| Protein | |||||
| HMGCS2 | 3-Hydroxy-3-methylglutaryl-coenzyme A synthase 2 | NM_005518 | 3158 | -2.9 | AR |
| MME | Membrane metalloendopeptidase | AL833459 | 4311 | -2.3 | |
| KLK3 | Kallikrein 3, (PSA) | CF140712 | 354 | -2.3 | AR, IFN |
| ODC1 | Ornithine decarboxylase 1 | BU153337 | 4953 | -1.9 | AR |
| GOT2 | Glutamic-oxaloacetic transaminase 2, mitochondrial | AK098313 | 2806 | -1.7 | |
| ACY1L2 | Aminoacylase 1-like 2 | AK094996 | 135293 | -1.7 | |
| GBDR1 | Putative glioblastoma cell differentiation-related | BC004967 | 10422 | -1.7 | |
| ADAM23 | A disintegrin and metalloproteinase domain 23 | AF052115 | 8745 | -1.7 | |
| ALDH1A3 | Aldehyde dehydrogenase 1 family, member A3 | BX538027 | 220 | -1.6 | AR |
| KLK2 | Kallikrein 2, prostatic | NM_005551 | 3817 | -1.6 | AR |
| GOT1 | Glutamic-oxaloacetic transaminase 1, soluble | CR616132 | 2805 | -1.5 | AR |
| Other | |||||
| NDUFS3 | NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30 kDa | AF100743 | 4722 | -2.1 | |
| ACPP | Acid phosphatase, prostate | AI547266 | 55 | -2.1 | AR |
| DTYMK | Deoxythymidylate kinase | AA427388 | 1841 | -2.1 | |
| DCXR | Dicarbonyl/l-xylulose reductase | BM795570 | 51181 | -1.6 | |
| RRM1 | Ribonucleotide reductase M1 polypeptide | AK122695 | 6240 | -1.6 | |
| AK3 | Adenylate kinase 3 | AW014145 | 205 | -1.6 | |
| NME1 | Nonmetastatic cells 1, protein (NM23A) | NM_000269 | 4830 | -1.6 | E2 |
| Proliferation/differentiation/apoptosis | |||||
| CCDC5 | Coiled coil domain-containing 5 | AI142429 | 115106 | -2.0 | |
| TPT1 | Tumor protein, translationally controlled 1 | AU119000 | 7178 | -1.7 | |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 | BC005945 | 4085 | -1.6 | |
| PCNA | Proliferating cell nuclear antigen | AA953221 | 5111 | -1.6 | |
| CCNG2 | Cyclin G2 | CR598707 | 901 | -1.6 | |
| MCM3 | MCM3 minichromosome maintenance-deficient 3 | BQ213935 | 4172 | -1.5 | |
| Signal transduction | |||||
| FKBP5 | FK506-binding protein 5 | BU618502 | 2289 | -2.7 | AR |
| RACGAP1 | Rac GTPase-activating protein 1 | AB040911 | 29127 | -2.2 | |
| STMN1 | Stathmin 1/oncoprotein 18 | BM543057 | 3925 | -2.0 | |
| CAMKK2 | Calcium/calmodulin-dependent protein kinase kinase 2, β | NM_006549 | 10645 | -2.0 | AR |
| MAP2K1 | Mitogen-activated protein kinase kinase 1 | L05624 | 5604 | -1.9 | IFN |
| RAB27A | RAB27A, member RAS oncogene family | U38654 | 5873 | -1.9 | |
| GNB2L1 | Guanine nucleotide-binding protein (G protein), β polypeptide 2-like 1 | BE300778 | 10399 | -1.8 | |
| MAP2K4 | Mitogen-activated protein kinase kinase 4 | NM_003010 | 6416 | -1.7 | |
| SLC9A3R2 | Solute carrier family 9, isoform 3 regulatory factor 2 | BU540416 | 9351 | -1.7 | |
| TM4SF3 | Transmembrane 4 superfamily member 3 | NM_004616 | 7103 | -1.6 | |
| APPBP1 | Amyloid β precursor protein-binding protein 1, 59 kDa | BC041323 | 8883 | -1.6 | |
| CCL2 | Chemokine (C-C motif) ligand 2 | BU532858 | 6347 | -1.6 | |
| RAN | RAN, member RAS oncogene family | BG775164 | 5901 | -1.5 | |
| Structure/adhesion/motility | |||||
| DKFZP761D0211 | Hypothetical protein DKFZp761D0211 | CR619764 | 83986 | -2.1 | |
| COL1A1 | Collagen, type I, α1 | CV799740 | 1277 | -2.1 | |
| HMMR | Hyaluronan-mediated motility receptor | CR601287 | 3161 | -2.0 | |
| COL2A1 | Collagen, type II, α1 | CX119275 | 1280 | -1.8 | |
| TSPAN-1 | Tetraspan 1 | CA454232 | 10103 | -1.7 | |
| Postn | periostin, osteoblast-specific factor (M. musculus) | BC031449 | 50706 | -1.7 | |
| LCP1 | Lymphocyte cytosolic protein 1 | BC015001 | 3936 | -1.7 | |
| MYBPC1 | Myosin-binding protein C, slow type | BF516586 | 4604 | -1.6 | |
| Structure/adhesion/motility | |||||
| SMOC1 | SPARC-related modular calcium-binding 1 | CD049369 | 64093 | -1.6 | |
| NUP93 | Nucleoporin 93 kDa | CR612078 | 9688 | -1.6 | |
| SYNPO2 | Synaptopodin 2 | AL833547 | 171024 | -1.5 | |
| CKAP5 | Cytoskeleton-associated protein 5 | CR623748 | 9793 | -1.5 | |
| CXCR4 | Chemokine (C-X-C motif) receptor 4 | BF591711 | 7852 | -1.5 | |
| Transcription regulation | |||||
| NKX3-1 | NK3 transcription factor-related, locus 1 | BX102941 | 4824 | -3.3 | |
| SPDEF | SAM-pointed domain-containing ets transcription factor | BG328411 | 25803 | -2.5 | |
| TOP2A | Topoisomerase (DNA) II α 170 kDa | AW172827 | 7153 | -2.3 | E2 |
| CREB3L4 | cAMP-responsive element-binding protein 3-like 4 | AF394167 | 148327 | -2.3 | |
| H2AFZ | H2A histone family, member Z | BU178992 | 3015 | -1.9 | |
| RFC3 | Replication factor C3, 38 kDa | BC000149 | 5983 | -1.9 | |
| CDK2AP1 | CDK2-associated protein 1 | BU608264 | 8099 | -1.8 | |
| SMARCA2 | SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 2 | BM671383 | 6595 | -1.6 | |
| SMC2L1 | SMC2 structural maintenance of chromosomes 2-like 1 | BC032705 | 10592 | -1.5 | |
| SNRPB | Small nuclear ribonucleoprotein polypeptides B and B1 | BX363533 | 6628 | -1.5 | |
| RAD51C | RAD51 homolog C | AW270829 | 5889 | -1.5 | |
| HIRIP3 | HIRA-interacting protein 3 | NM_003609 | 8479 | -1.5 | |
| Translation-protein synthesis | |||||
| GOLPH2 | Golgi phosphoprotein 2 | AW591201 | 51280 | -2.6 | |
| RPS2 | Ribosomal protein S2 | CR610190 | 6187 | -2.3 | |
| RPL4 | Ribosomal protein L4 | BM451248 | 6124 | -2.2 | |
| NAG | Neuroblastoma-amplified protein | NM_015909 | 51594 | -2.1 | |
| LOC388817 | Peptidylprolyl isomerase A-like | BM972350 | 388817 | -2.1 | |
| LRIG1 | Leucine-rich repeats and immunoglobulin-like domains 1 | BC014276 | 26018 | -2.0 | |
| EEF1A1 | Eukaryotic translation elongation factor 1 α1 | BC020477 | 1915 | -1.9 | |
| RPS8 | Ribosomal protein S8 | BQ218087 | 6202 | -1.9 | |
| RAI14 | Retinoic acid-induced 14 | AY317139 | 26064 | -1.8 | |
| RPL6 | Ribosomal protein L6 | BC071912 | 6128 | -1.8 | |
| RPL9 | Ribosomal protein L9 | BQ961538 | 6133 | -1.8 | |
| RPL10A | Ribosomal protein L10a | BQ941098 | 4736 | -1.7 | |
| EEF1B2 | Eukaryotic translation elongation factor 1 β2 | BX353697 | 1933 | -1.7 | |
| RPS6 | Ribosomal protein S6 | BG029552 | 6194 | -1.6 | |
| RPL26 | Ribosomal protein L26 | BG925676 | 6154 | -1.6 | |
| RPL31 | Ribosomal protein L31 | CN269893 | 6160 | -1.6 | |
| RPL5 | Ribosomal protein L5 | BM721056 | 6125 | -1.6 | |
| NACA | Nascent polypeptide-associated complex α polypeptide | BU164695 | 4666 | -1.6 | |
| RPL13A | Ribosomal protein L13a | BQ229130 | 23521 | -1.6 | |
| EIF3S6IP | Eukaryotic translation initiation factor 3, subunit 6-interacting protein | BX424780 | 51386 | -1.6 | |
| RPL11 | Ribosomal protein L11 | BU902342 | 6135 | -1.6 | |
| RPS3A | Ribosomal protein S3A | BM463771 | 6189 | -1.5 | |
| RPS15A | Ribosomal protein S15a | CN351294 | 6210 | -1.5 | |
| RPLP0 | Ribosomal protein, large, P0 | BG575128 | 6175 | -1.5 | |
| RPS13 | Ribosomal protein S13 | CA843734 | 6207 | -1.5 | |
| RPL10 | Ribosomal protein L10 | BM423499 | 6134 | -1.5 | |
| RPS4X | Ribosomal protein S4, X-linked | BQ959684 | 6191 | -1.5 | |
| Transport | |||||
| DBI | Diazepam-binding inhibitor | BQ940531 | 1622 | -2.5 | |
| VPS45A | Vacuolar protein sorting 45A | AK023170 | 11311 | -2.2 | |
| HBE1 | Hemoglobin, epsilon 1 | AA115963 | 3046 | -2.0 | |
| SLC39A6 | Solute carrier family 39, member 6 | BC008317 | 25800 | -1.7 | |
| RAB3B | RAB3B, member RAS oncogene family | BF792558 | 5865 | -1.7 | |
| KPNA2 | Karyopherin α2 | U09559 | 3838 | -1.6 | |
| TOMM40 | Translocase of outer mitochondrial membrane 40 homolog | BQ883428 | 10452 | -1.6 | |
| SLC16A1 | Solute carrier family 16, member 1 | AK000641 | 6566 | -1.6 | AR |
| SLC25A3 | Solute carrier family 25, member 3 | BC068067 | 5250 | -1.5 | |
| ATP5B | ATP synthase, H+-transporting, mitochondrial F1 complex, β polypeptide | CR591449 | 506 | -1.5 | |
| Other/unknown | |||||
| KIAA0114 | KIAA0114 gene product | BI850303 | 57291 | -2.3 | |
| BRP44 | Brain protein 44 | BQ287816 | 25874 | -2.2 | |
| THAP5 | THAP domain-containing 5 | NM_182529 | 168451 | -2.0 | |
| HN1 | Hematological and neurological expressed 1 | CN363269 | 51155 | -2.0 | |
| KIAA0460 | KIAA0460 protein | AB007929 | 23248 | -2.0 | |
| PRAC | Small nuclear protein PRAC | BU942850 | 84366 | -1.8 | |
| SURF4 | Surfeit 4 | CR602588 | 6836 | -1.7 | |