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The C elegans apoptosome and its mechanism of activation. In the inactive state the ternary complex (CED-3, CED-4, and CED-9) is assembled on mitochondria. An unspecified death signal mobilizes EGL-1. In turn, EGL-1 binds CED-9, disengaging the apoptosome. CED-4 proceeds to oligomerize and induce the proximity and consequent activation of proCED-3 molecules.
