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. 2006 Dec 21;104(1):359–364. doi: 10.1073/pnas.0609713104

Fig. 5.

Fig. 5.

Toxicity of scBoNT/B and wild-type BoNT/G-Thro and selected mutants having a deactivated ganglioside binding site (W1262L, W1268L) or Syt binding site (K1192E, Q1200K) at the phrenic nerve preparations of wild-type (black columns) and complex-ganglioside-deficient (white columns) mice. To dose–response curves of recombinant wild-type scBoNT/B and wild-type BoNT/G-Thro a power function was fitted. The resulting paralytic halftimes of scBoNT/B or BoNT/G-Thro mutants were converted to the corresponding concentrations of wild-type BoNTs by using the power functions. The toxicities were finally expressed relative to wild-type BoNT.