Table 4.

Predictors of Physical health MSQoL-54 scales by IFN-β treatment (Multivariate hierarchical analysis)

	Energy		Health perceptions		Physical function		Role limitation physical		Bodily pain		Social function
Effect	β	p	β	p	β	p	β	p	β	p	β	p
Intercept*	45.11	<.0001	44.67	<.0001	69.40	<.0001	71.72	<.0001	74.23	<.0001	72.54	<.0001
Age at inclusion	-0.12	0.36	0.06	0.68	-0.4	0.01	-0.60	0.03	-0.36	0.04	0.06	0.66
Gender (Male vs. Female)	-0.51	0.84	2.00	0.52	1.07	0.75	-17.3	0.003	3.74	0.31	-0.32	0.90
Disease duration	-0.02	0.92	-0.36	0.08	0.10	0.64	0.19	0.60	-0.38	0.12	-0.30	0.10
Disease course (SP vs. RR)	9.54	0.03	7.35	0.16	-8.44	0.12	8.77	0.34	17.33	0.004	8.65	0.06
Relapse rate 2-yrs before study entry	0.37	0.90	-2.01	0.58	0.70	0.86	1.39	0.83	-0.20	0.96	3.76	0.24
EDSS	-2.33	0.06	-3.54	0.02	-8.44	<.0001	-4.69	0.09	-2.82	0.11	-2.65	0.05
BDI	-1.16	<.0001	-0.26	0.20	0.25	0.26	-0.92	0.01	0.22	0.36	-0.66	0.0004
FSS	-4.80	<.0001	-6.8	<.0001	-8.69	<.0001	-10.0	<.0001	-9.74	<.0001	-6.72	<.0001
MMSE-c	-0.19	0.71	-0.43	0.46	0.05	0.94	-1.90	0.10	0.02	0.98	-0.30	0.57
IFN-β treatment (Yes vs No)	1.43	0.65	3.56	0.32	1.20	0.77	5.03	0.50	4.54	0.32	0.23	0.94
Relapse rate change after 2-yrs	4.96	0.17	2.40	0.61	3.76	0.20	-2.71	0.69	2.96	0.54	6.77	0.08
EDSS change after 2-yrs	-0.11	0.95	-1.49	0.54	-4.54	0.003	0.59	0.86	0.70	0.77	-2.72	0.16
BDI change after 2-yrs	-0.67	0.0005	-0.48	0.05	-0.14	0.37	-1.59	<.0001	-0.82	0.002	-0.67	0.001
FSS change after 2-yrs	-5.20	<.0001	-4.89	0.001	-4.65	<.0001	-4.75	0.03	-5.98	0.0001	-4.39	0.0003
MMSE-c change after 2-yrs	-1.09	0.15	0.20	0.84	-0.10	0.87	-3.04	0.04	-0.64	0.53	0.18	0.81
Time**	8.67	0.004	3.36	0.37	-4.84	0.05	-1.00	0.86	-1.81	0.65	0.64	0.84
Time × IFN-β treatment (Yes vs No)	-0.76	0.86	-1.72	0.74	-6.15	0.07	-2.54	0.77	3.82	0.50	-1.73	0.69

*Intercept value represents the baseline mean score for reference group (Untreated)

**Time value represents the mean score change for reference group (Untreated) after 2 years of follow-up