Table 5.

Predictors of Mental health MSQoL-54 scales by IFN-β treatment (Multivariate hierarchical analysis)

	Emotional well being		Role limitation emotional		Health distress		Cognitive function		Overall quality of life
Effect	β	p	β	p	β	p	β	p	β	p
Intercept*	73.6	<.0001	53.68	<.0001	69.6	<.0001	78.3	<.0001	68.6	<.0001
Age at inclusion	-0.31	0.32	-0.11	0.45	0.08	0.57	-0.41	0.01	0.02	0.86
Gender (Male vs. Female)	-19.83	0.003	1.68	0.57	-3.69	0.19	-8.55	0.01	-4.05	0.14
Disease duration	-0.29	0.49	0.13	0.50	0.08	0.69	-0.16	0.49	0.13	0.49
Disease course (SP vs. RR)	15.2	0.15	8.75	0.08	4.21	0.37	14.8	0.008	-2.55	0.57
Relapse rate 2-yrs before study entry	-0.31	0.97	0.15	0.96	-0.31	0.92	-0.40	0.92	-1.40	0.66
EDSS	1.15	0.71	-2.13	0.14	-0.11	0.93	-0.70	0.67	-1.51	0.25
BDI	-1.50	<.0007	-1.86	<.0001	-1.75	<.0001	-1.01	<.0001	-1.35	<.0001
FSS	-8.33	<.0005	1.67	0.12	-2.86	0.005	-1.06	0.38	0.02	0.98
MMSE-c	0.15	0.91	0.42	0.44	0.84	0.11	1.69	0.009	0.39	0.46
IFN-β treatment (Yes vs No)	7.67	0.34	5.22	0.13	4.99	0.13	3.12	0.44	-1.16	0.73
Relapse rate change after 2-yrs	-4.36	0.57	3.64	0.39	-1.90	0.72	2.90	0.51	-3.34	0.35
EDSS change after 2-yrs	2.95	0.44	-1.32	0.54	1.57	0.56	3.09	0.17	-0.24	0.89
BDI change after 2-yrs	-1.65	<.0001	-1.20	<.0001	-0.84	0.003	-0.91	.0001	-1.15	<.0001
FSS change after 2-yrs	-3.63	0.13	-1.14	0.38	-3.66	0.02	-0.20	0.88	-2.65	0.02
MMSE-c change after 2-yrs	-1.29	0.42	0.58	0.50	1.42	0.20	0.04	0.97	-1.40	0.6
Time**	5.68	0.37	5.31	0.11	4.15	0.32	-0.64	0.86	0.31	0.91
Time × IFN-β treatment (Yes vs no)	-19.11	0.03	-4.95	0.27	-12.29	0.03	-9.65	0.05	2.53	0.54

*Intercept value represents the baseline mean score for reference group (Untreated)

**Time value represents the mean score change for reference group (Untreated) after 2 years of follow-up