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. 1997 Apr;76(4):345–348. doi: 10.1136/adc.76.4.345

Non-infective colitis in infancy: evidence in favour of minor immunodeficiency in its pathogenesis

A Ojuawo 1, D S Louis 1, K Lindley 1, P Milla 1
PMCID: PMC1717128  PMID: 9166029

Abstract

Accepted 4 November 1996


Forty two infants below the age of 2 years presenting with chronic non-infective diarrhoea and shown to have histologically proved colitis were investigated over a five year period. Allergic colitis was the most common cause of colitis, accounting for 62% of the cases. Other colitides diagnosed included: non-specific colitis, autoimmune enterocolitis, and ulcerative colitis accounting for 10% each; severe combined immunodeficiency 7%, and Crohn's disease 3%. A positive family history and a personal history of atopy were obtained in 48% and 29% of the cases respectively. Serum immunoglobulin A, IgG2, and IgG4 were very low in over 50% of the entire cohort of infants with colitis; 66% of those with severe combined immunodeficiency, autoimmune enterocolitis, and ulcerative colitis (n = 11) had low CD3 and CD4 T lymphocytes with an accompanying increase in CD8 in two thirds of those with severe combined immunodeficiency. T lymphocytes were normal in those with allergic colitis. Thus infants with proved non-infective colitis as a group show a high prevalence of IgA, IgG2, and IgG4 deficiency. It is likely that this minor deficiency of mucosa associated immunoglobulin production has a role in the pathogenesis of the colitic process.



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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Booth I. W., Harries J. T. Inflammatory bowel disease in childhood. Gut. 1984 Feb;25(2):188–202. doi: 10.1136/gut.25.2.188. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brandtzaeg P., Halstensen T. S., Kett K., Krajci P., Kvale D., Rognum T. O., Scott H., Sollid L. M. Immunobiology and immunopathology of human gut mucosa: humoral immunity and intraepithelial lymphocytes. Gastroenterology. 1989 Dec;97(6):1562–1584. doi: 10.1016/0016-5085(89)90406-x. [DOI] [PubMed] [Google Scholar]
  3. Buchino J. J., Suchy F. J., Snyder J. W. Bacterial diarrhea in infants and children. Perspect Pediatr Pathol. 1984 Summer;8(2):163–180. [PubMed] [Google Scholar]
  4. Chong S. K., Blackshaw A. J., Morson B. C., Williams C. B., Walker-Smith J. A. Prospective study of colitis in infancy and early childhood. J Pediatr Gastroenterol Nutr. 1986 May-Jun;5(3):352–358. doi: 10.1097/00005176-198605000-00003. [DOI] [PubMed] [Google Scholar]
  5. Gilat T., Hacohen D., Lilos P., Langman M. J. Childhood factors in ulcerative colitis and Crohn's disease. An international cooperative study. Scand J Gastroenterol. 1987 Oct;22(8):1009–1024. doi: 10.3109/00365528708991950. [DOI] [PubMed] [Google Scholar]
  6. Gryboski J. D. Gastrointestinal milk allergy in infants. Pediatrics. 1967 Sep;40(3):354–362. [PubMed] [Google Scholar]
  7. Gryboski J. D. Ulcerative colitis in children 10 years old or younger. J Pediatr Gastroenterol Nutr. 1993 Jul;17(1):24–31. doi: 10.1097/00005176-199307000-00004. [DOI] [PubMed] [Google Scholar]
  8. Heiner D. C. Significance of immunoglobulin G subclasses. Am J Med. 1984 Mar 30;76(3A):1–6. doi: 10.1016/0002-9343(84)90313-9. [DOI] [PubMed] [Google Scholar]
  9. Hill S. M., Milla P. J., Bottazzo G. F., Mirakian R. Autoimmune enteropathy and colitis: is there a generalised autoimmune gut disorder? Gut. 1991 Jan;32(1):36–42. doi: 10.1136/gut.32.1.36. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hill S. M., Milla P. J. Colitis caused by food allergy in infants. Arch Dis Child. 1990 Jan;65(1):132–133. doi: 10.1136/adc.65.1.132. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hollander D., Vadheim C. M., Brettholz E., Petersen G. M., Delahunty T., Rotter J. I. Increased intestinal permeability in patients with Crohn's disease and their relatives. A possible etiologic factor. Ann Intern Med. 1986 Dec;105(6):883–885. doi: 10.7326/0003-4819-105-6-883. [DOI] [PubMed] [Google Scholar]
  12. Jenkins H. R., Pincott J. R., Soothill J. F., Milla P. J., Harries J. T. Food allergy: the major cause of infantile colitis. Arch Dis Child. 1984 Apr;59(4):326–329. doi: 10.1136/adc.59.4.326. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Odze R. D., Bines J., Leichtner A. M., Goldman H., Antonioli D. A. Allergic proctocolitis in infants: a prospective clinicopathologic biopsy study. Hum Pathol. 1993 Jun;24(6):668–674. doi: 10.1016/0046-8177(93)90248-f. [DOI] [PubMed] [Google Scholar]
  14. Oxelius V. A. Immunoglobulin G (IgG) subclasses and human disease. Am J Med. 1984 Mar 30;76(3A):7–18. doi: 10.1016/0002-9343(84)90314-0. [DOI] [PubMed] [Google Scholar]
  15. Powell G. K. Milk- and soy-induced enterocolitis of infancy. Clinical features and standardization of challenge. J Pediatr. 1978 Oct;93(4):553–560. doi: 10.1016/s0022-3476(78)80887-7. [DOI] [PubMed] [Google Scholar]
  16. Robson W. L., Leung A. K., Miller-Hughes D. J. Recurrent hemorrhagic colitis caused by Escherichia coli O157:H7. Pediatr Infect Dis J. 1993 Aug;12(8):699–701. doi: 10.1097/00006454-199308000-00018. [DOI] [PubMed] [Google Scholar]
  17. Sanderson I. R. Unusual colitides. Baillieres Clin Gastroenterol. 1994 Mar;8(1):181–196. doi: 10.1016/s0950-3528(06)80025-4. [DOI] [PubMed] [Google Scholar]
  18. Scott M. G., Nahm M. H., Macke K., Nash G. S., Bertovich M. J., MacDermott R. P. Spontaneous secretion of IgG subclasses by intestinal mononuclear cells: differences between ulcerative colitis, Crohn's disease, and controls. Clin Exp Immunol. 1986 Oct;66(1):209–215. [PMC free article] [PubMed] [Google Scholar]
  19. Walker W. A., Bloch K. J. Intestinal uptake of macromolecules: in vitro and in vivo studies. Ann N Y Acad Sci. 1983 Jun 30;409:593–602. doi: 10.1111/j.1749-6632.1983.tb26901.x. [DOI] [PubMed] [Google Scholar]
  20. Whittam T. S., Wolfe M. L., Wachsmuth I. K., Orskov F., Orskov I., Wilson R. A. Clonal relationships among Escherichia coli strains that cause hemorrhagic colitis and infantile diarrhea. Infect Immun. 1993 May;61(5):1619–1629. doi: 10.1128/iai.61.5.1619-1629.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]

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