Abstract
Antimicrobial MIC data were obtained for 96 strains of Staphylococcus haemolyticus and the following 11 antimicrobial agents: methicillin, gentamicin, rifampin, fusidic acid, ciprofloxacin, vancomycin, teicoplanin; three experimental glycopeptides, MDL 62,873, MDL 62,208, and MDL 62,224; and an experimental lipoglycopeptide, ramoplanin. Resistance to methicillin and gentamicin was present in over 50% of the strains, although resistance to the other agents was present in less than 10%. It is shown how application of mathematical modeling techniques can add to the understanding of such MIC data. MICs of methicillin and gentamicin were highly correlated, suggesting that evolutionary pressures for development of resistance to these agents were similar. The structural relationships among the glycopeptides were accurately reflected in their spatial relationships within the model. MICs of ramoplanin were negatively correlated with MICs of some other antimicrobial agents, particularly gentamicin, suggesting that this agent is more active against gentamicin-resistant strains. Methicillin-resistant strains were more tightly clustered than were methicillin-susceptible strains, suggesting that methicillin-resistant strains were more closely related to each other than were methicillin-susceptible strains. Mathematical modeling techniques enable more detailed analysis of MIC data.
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- Eng R. H., Wang C., Person A., Kiehn T. E., Armstrong D. Species identification of coagulase-negative staphylococcal isolates from blood cultures. J Clin Microbiol. 1982 Mar;15(3):439–442. doi: 10.1128/jcm.15.3.439-442.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Froggatt J. W., Johnston J. L., Galetto D. W., Archer G. L. Antimicrobial resistance in nosocomial isolates of Staphylococcus haemolyticus. Antimicrob Agents Chemother. 1989 Apr;33(4):460–466. doi: 10.1128/aac.33.4.460. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gruer L. D., Bartlett R., Ayliffe G. A. Species identification and antibiotic sensitivity of coagulase-negative staphylococci from CAPD peritonitis. J Antimicrob Chemother. 1984 Jun;13(6):577–583. doi: 10.1093/jac/13.6.577. [DOI] [PubMed] [Google Scholar]
- Hamilton-Miller J. M., Iliffe A. Antimicrobial resistance in coagulase-negative staphylococci. J Med Microbiol. 1985 Apr;19(2):217–226. doi: 10.1099/00222615-19-2-217. [DOI] [PubMed] [Google Scholar]
- Malabarba A., Trani A., Strazzolini P., Cietto G., Ferrari P., Tarzia G., Pallanza R., Berti M. Synthesis and biological properties of N63-carboxamides of teicoplanin antibiotics. Structure-activity relationships. J Med Chem. 1989 Nov;32(11):2450–2460. doi: 10.1021/jm00131a007. [DOI] [PubMed] [Google Scholar]
- Marples R. R., Hone R., Notley C. M., Richardson J. F., Crees-Morris J. A. Ivestigation of coagulase-negative staphylococci from infections in surgical patients. Zentralbl Bakteriol Orig A. 1978 Jul;241(1):140–156. [PubMed] [Google Scholar]
- Marsik F. J., Brake S. Species identification and susceptibility to 17 antibiotics of coagulase-negative staphylococci isolated from clinical specimens. J Clin Microbiol. 1982 Apr;15(4):640–645. doi: 10.1128/jcm.15.4.640-645.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schwalbe R. S., Stapleton J. T., Gilligan P. H. Emergence of vancomycin resistance in coagulase-negative staphylococci. N Engl J Med. 1987 Apr 9;316(15):927–931. doi: 10.1056/NEJM198704093161507. [DOI] [PubMed] [Google Scholar]