Table 3.
Genes correlated with the development of hyperglycemia
| Accession no. | Description | r value | Fold | Accession
no. |
Description | r value | Fold | ||
|---|---|---|---|---|---|---|---|---|---|
| Signal
transduction |
Transcription
factors |
||||||||
| M34397 | IL-3 receptor-like protein | −0.955 | −3.5 | W87135 | Single stranded DNA binding protein p9 | 0.973 | 2.2 | ||
| aa097386 | Similar to CAM-like protein kinase | −0.982 | n/a | af003866 | Pale ear (ep wild type allele) | −0.982 | −2.1 | ||
| U58889 | SH3-containing protein (SH3P3) | −0.970 | n/a | AB001990 | Dcra | −0.985 | −1.4 | ||
| u35124 | Nonreceptor tyrosine phosphatase | −0.968 | n/a | m11943 | Int-1 proto-oncogene | 0.956 | 4 | ||
| d31943 | Cytokine inducible SH2-containing protein | −0.971 | −2.2 | u67840 | Dlx5 | −0.988 | n/a | ||
| u60528 | Guanylin precursor gene | 0.963 | n/a | Z32675 | Hairless protein | −0.956 | −1.9 | ||
| aa217487 | Similar to mouse pim-1 protein kinase | −0.972 | n/a | AJ002366 | Transcription factor TFIIH, 62 kD subunit | −0.968 |
n/a | ||
| m64689 | flk-2 | 0.972 | n/a | U41285 | Dishevelled-3 (Dvl-3) | −0.951 | −1.5 | ||
| C79373 | Similar to phosphatase inhibitor-2 | 0.952 | 1.5 | L38607 | BF-2 transcription factor | 0.994 | n/a | ||
| aa105135 | Similar to P53-binding protein | −0.982 | −2.4 | aa710439 | BACH1 | −0.986 | n/a | ||
| aa467011 | Similar to LMW G-protein | 0.955 | n/a | W83286 | Similar to H. sapiens RNA polymerase II | 0.967 | 1.4 | ||
| d83266 | vav-T | −0.958 | n/a | D14336 | RNA polymerase I associated factor | −0.972 | −1.5 | ||
| W91283 | Similar to human ras-like protein | 0.989 | 1.6 | Others | |||||
| C81377 | Similar to rat activated c-raf oncogene | 0.960 | n/a | aa711217 | Similar to NADH-ubiquinone oxidoreductase | 0.960 | 1.4 | ||
| u70324 | Fyn(T) | 0.965 | n/a | aa521794 | Similar to cytochrome c oxidase | −0.961 | −1.6 | ||
| X72862 | β-3-adrenergic receptor | 0.951 | n/a | iM36660 | NAD(P)H menadione oxidoreductase | −0.958 | n/a | ||
| 101695 | Calmodulin-dependent phosphodiesterase | −0.960 | −1.2 | af015284 | Selenoprotein W (mSelW) | −0.992 | n/a | ||
| x04648 | IgG1/IgG2β Fc receptor (FcR) | −0.961 | −3.3 | M99054 | Acid phosphatase type 5 gene | −0.960 | −1.5 | ||
| Secreted | aa543785 | Thymic dendritic cell-derived factor 1 | 0.985 | 1.5 | |||||
| M33960 | Plasminogen activator inhibitor (PAI-1) | 0.962 | 2.2 | J02809 | Neural specific calmodulin-binding protein | −0.954 | n/a | ||
| D38580 | VNSP I(vomeronasal secretory protein I) | −0.962 | n/a | aa061099 | Ribonuclease HI | −0.980 | −3.3 | ||
| Protein synthesis and processing | C78741 | Poly(A) binding protein II (mPABII) | −0.951 | −1.4 | |||||
| aa036204 | Similar to human 40S ribosomal protein S24 | 0.971 | 1.7 | AA230943 | Similar to mouse Sm-B | −0.952 | −2.1 | ||
| D12907 | 47-kDa heat shock protein (HSP47) | −0.966 | −1.6 | aa544831 | Similar to renin-binding protein | −0.973 | −2.5 | ||
| 125913 | Chaperonin | 0.999 | 1.5 | U12564 | 129 defensin-like gene 4C-2 | 0.971 | n/a | ||
| C77806 | Similar to rat carboxypeptidase B gene | −0.960 | n/a | c79315 | Similar to M. musculus tex292 | 0.971 | 1.6 | ||
| aa270493 | Similar to deoxyhypusine synthase | −0.959 | −2.4 | L06234 | Dihydropyridine-sensitive calcium channel | −0.969 | n/a | ||
| aa611449 | Similar to Homo sapiens HSPC183 | −0.962 | −2.6 | U62021 | Neuronal pentraxin 1 (NPTX1) | −0.951 | −2.1 | ||
| AA105758 | MDj10 | −0.974 | −2.2 | aa560507 | Similar to antiquitin | −0.984 | −1.6 | ||
| Cytoskeletal and ECM | z72000 | BTG3 | 0.959 | 2.1 | |||||
| M25825 | tctex-1 | −0.959 | −1.9 | af003346 | Ubiquitin-conjugating enzyme UbcM2 | 0.982 | 1.7 | ||
| C77864 | Similar to Chinese hamster for β tubulin | −0.991 | n/a | AA072822 | Testosterone 15-α-hydroxylase | −0.957 | n/a | ||
| aa111610 | Similar to tuftelin-interacting protein 10 | 0.950 | n/a | aa547057 | Similar to HT Protein | −0.979 | −1.4 | ||
| AA138226 | Similar to rat clathrin light chain (LCB3) | 0.956 | 1.1 | Metabolism | |||||
| m75720 | α-1 protease inhibitor 3 | 0.955 | n/a | AA146156 | Keratinocyte lipid binding protein (Klbp) | 0.986 | 8.6 | ||
| C76274 | Similar to Mus musculus ligatin (Lgtn) | −0.952 | n/a | AA120674 | Similar to Homo sapiens acylphosphatase 2 | 0.964 | 2.3 | ||
| aa204573 | Similar to human spindle pole body protein | −0.972 | −1.5 | U21489 | Long-chain acyl-CoA dehydrogenase | −0.963 | −1.6 | ||
| aa592828 | Aldo-keto reductase AKR1C1 | 0.977 | 2.2 | ||||||
| ET63206 | Fructose-1,6-bisphosphatase | 0.960 | n/a | ||||||
r values were calculated using the rank order of the five sets of animals with increasing hyperglycemia. Fold changes represented by n/a mean that the mRNA level increased from, or decreased to, an expression level outside the linear range of detection.