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. 1990 Dec;34(12):2415–2416. doi: 10.1128/aac.34.12.2415

Inhibition of Amphotericin B (Fungizone) Toxicity to Cells by Egg Lecithin-Glycocholic Acid Mixed Micelles

Janina Brajtburg 1,*, Svetlana Elberg 1, George S Kobayashi 2,3, Gerald Medoff 1,3
PMCID: PMC172071  PMID: 2088196

Abstract

Mixed micelles prepared from egg lecithin and the sodium salt of glycocholic acid markedly inhibited amphotericin B toxicity to mammalian cells without significantly affecting the antifungal effects of the drug.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brajtburg J., Powderly W. G., Kobayashi G. S., Medoff G. Amphotericin B: current understanding of mechanisms of action. Antimicrob Agents Chemother. 1990 Feb;34(2):183–188. doi: 10.1128/aac.34.2.183. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brajtburg J., Powderly W. G., Kobayashi G. S., Medoff G. Amphotericin B: delivery systems. Antimicrob Agents Chemother. 1990 Mar;34(3):381–384. doi: 10.1128/aac.34.3.381. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Gruda I., Gauthier E., Elberg S., Brajtburg J., Medoff G. Effects of the detergent sucrose monolaurate on binding of amphotericin B to sterols and its toxicity for cells. Biochem Biophys Res Commun. 1988 Aug 15;154(3):954–958. doi: 10.1016/0006-291x(88)90232-x. [DOI] [PubMed] [Google Scholar]
  4. Janoff A. S., Boni L. T., Popescu M. C., Minchey S. R., Cullis P. R., Madden T. D., Taraschi T., Gruner S. M., Shyamsunder E., Tate M. W. Unusual lipid structures selectively reduce the toxicity of amphotericin B. Proc Natl Acad Sci U S A. 1988 Aug;85(16):6122–6126. doi: 10.1073/pnas.85.16.6122. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Jullien S., Brajtburg J., Bolard J. Affinity of amphotericin B for phosphatidylcholine vesicles as a determinant of the in vitro cellular toxicity of liposomal preparations. Biochim Biophys Acta. 1990 Jan 15;1021(1):39–45. doi: 10.1016/0005-2736(90)90381-w. [DOI] [PubMed] [Google Scholar]
  6. Mehta R., Lopez-Berestein G., Hopfer R., Mills K., Juliano R. L. Liposomal amphotericin B is toxic to fungal cells but not to mammalian cells. Biochim Biophys Acta. 1984 Mar 14;770(2):230–234. doi: 10.1016/0005-2736(84)90135-4. [DOI] [PubMed] [Google Scholar]
  7. Saletu B., Anderer P., Kinsperger K., Grünberger J., Sieghart W. Comparative bioavailability studies with a new mixed-micelles solution of diazepam utilizing radioreceptor assay, psychometry and EEG brain mapping. Int Clin Psychopharmacol. 1988 Oct;3(4):287–323. doi: 10.1097/00004850-198810000-00002. [DOI] [PubMed] [Google Scholar]
  8. Son K., Alkan H. Liposomes prepared dynamically by interactions between bile salt and phospholipid molecules. Biochim Biophys Acta. 1989 Jun 6;981(2):288–294. doi: 10.1016/0005-2736(89)90039-4. [DOI] [PubMed] [Google Scholar]
  9. Szoka F. C., Jr, Milholland D., Barza M. Effect of lipid composition and liposome size on toxicity and in vitro fungicidal activity of liposome-intercalated amphotericin B. Antimicrob Agents Chemother. 1987 Mar;31(3):421–429. doi: 10.1128/aac.31.3.421. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Teelmann K., Schläppi B., Schüpbach M., Kistler A. Preclinical safety evaluation of intravenously administered mixed micelles. Arzneimittelforschung. 1984;34(11):1517–1523. [PubMed] [Google Scholar]

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