Figure 1 .

(A) Representative T2 weighted magnetic resonance (MR) images, (B) ¹H MR spectra, and (C) ³¹P MR spectra from healthy infants at 30 weeks gestation, term, 6 months, and 1 year of age. (A) The MR images show an increase in volume, surface area, and sulcation of cerebral cortex and in volume and microstructural organisation of cerebral white matter with development. (B) The series of ¹H MR spectra show a steady increase in N-acetyl aspartate (NAA; a marker of neuronal and axonal density and viability) and a decrease in brain lactate with maturation. (C) The series of ³¹P MR spectra show changing ratios of brain phospholipids and increasing energy state with maturation. PME, Phosphomonoesters; Pi, inorganic phosphate; PDE, phosphodiesters; PCr, phosphocreatine; ATP, adenosine triphosphate; Cho, choline; Cr, creatine; lac, lactate.