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(A) 1H MR spectrum from left basal ganglia showing appreciably raised lactate and reduced N-acetyl aspartate (NAA). (B) 31P MR spectrum from the whole brain showing severe secondary energy failure with phosphocreatine (PCr) and ATP depletion and increased inorganic phosphate (Pi). The brain pHi was alkaline (7.18). PME, Phosphomonoesters; PDE, phosphodiesters; Cho, choline; Cr, creatine; mI, myo-inositol; lac, lactate.
