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. 2000 Oct 3;97(21):11445–11450. doi: 10.1073/pnas.200363097

Figure 5.

Figure 5

(A) Spontaneous lysis of YAC-1 cells by the IL-15Tg(K2) splenic cells. The effector/target ratio was compensated for based on the percentage of NK cells in the splenic lymphocytes. (B) Depletion of NK cells using the anti-asialo GM1 antibody abrogated the constitutive lytic activity to YAC-1 cells of the IL-15Tg(K2) splenic cells. The injection (i.p.) of the anti-asialo GM1 antibody resulted in rapid disappearance of NK cells from the spleen of the IL-15Tg mouse (8% to 0.3% within 24 h of injection). The NK-depleted splenic lymphocytes were then tested for cytotoxicity.