Abstract
AIMS/BACKGROUND—It has been reported that the number of optic nerve fibres decrease with age, and the cup/disc (C/D) ratio increases as the optic disc size increases. Consequently, the normal value of the optic disc variables measured by an optic disc analyser may change according to the optic disc size or age. The effect of individual variations in optic disc size or age on interpretation of optic disc variables was investigated. METHODS—Topographic optic disc variables of 104 normal Asian adults of both sexes aged 40 to 68 were measured using a confocal scanning laser ophthalmoscope (TopSS, Laser Diagnostic Technologies, Inc). Fourteen variables were evaluated according to the optic disc size or age. Statistical analysis was done by regression analysis. RESULTS—With an increase in optic disc size, the increase in cup shape, effective area, 1/2 depth area, C/D ratio, neuroretinal rim area, volume above, volume below, and 1/2 depth volume were statistically significant (p<0.05). However, contour variation, mean contour depth, average depth, maximum depth, average slope, and maximum slope were not affected (p>0.1). Age did not have any significant influence on optic disc variables (p>0.1). CONCLUSION—Optic disc size, but not age, should be considered in the interpretation of optic disc variables.
Full Text
The Full Text of this article is available as a PDF (87.1 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Balazsi A. G., Rootman J., Drance S. M., Schulzer M., Douglas G. R. The effect of age on the nerve fiber population of the human optic nerve. Am J Ophthalmol. 1984 Jun;97(6):760–766. doi: 10.1016/0002-9394(84)90509-9. [DOI] [PubMed] [Google Scholar]
- Bengtsson B. The alteration and asymmetry of cup and disc diameters. Acta Ophthalmol (Copenh) 1980 Oct;58(5):726–732. doi: 10.1111/j.1755-3768.1980.tb06685.x. [DOI] [PubMed] [Google Scholar]
- Bengtsson B. The variation and covariation of cup and disc diameters. Acta Ophthalmol (Copenh) 1976 Dec;54(6):804–818. doi: 10.1111/j.1755-3768.1976.tb01801.x. [DOI] [PubMed] [Google Scholar]
- Britton R. J., Drance S. M., Schulzer M., Douglas G. R., Mawson D. K. The area of the neuroretinal rim of the optic nerve in normal eyes. Am J Ophthalmol. 1987 Apr 15;103(4):497–504. doi: 10.1016/s0002-9394(14)74271-0. [DOI] [PubMed] [Google Scholar]
- Caprioli J., Miller J. M. Optic disc rim area is related to disc size in normal subjects. Arch Ophthalmol. 1987 Dec;105(12):1683–1685. doi: 10.1001/archopht.1987.01060120081030. [DOI] [PubMed] [Google Scholar]
- Carpel E. F., Engstrom P. F. The normal cup-disk ratio. Am J Ophthalmol. 1981 May;91(5):588–597. doi: 10.1016/0002-9394(81)90056-8. [DOI] [PubMed] [Google Scholar]
- Chihara E., Takahashi F., Chihara K. Assessment of optic disc topography with scanning laser ophthalmoscope. Graefes Arch Clin Exp Ophthalmol. 1993;231(1):1–6. doi: 10.1007/BF01681692. [DOI] [PubMed] [Google Scholar]
- Erkkilä H., Laatikainen L. Characteristics of optic disc in healthy school children. Acta Ophthalmol (Copenh) 1979 Oct;57(5):914–921. doi: 10.1111/j.1755-3768.1979.tb01858.x. [DOI] [PubMed] [Google Scholar]
- Funk J., Dieringer T., Grehn F. Correlation between neuroretinal rim area and age in normal subjects. Graefes Arch Clin Exp Ophthalmol. 1989;227(6):544–548. doi: 10.1007/BF02169450. [DOI] [PubMed] [Google Scholar]
- Funk J. Early detection of glaucoma by longitudinal monitoring of the optic disc structure. Graefes Arch Clin Exp Ophthalmol. 1991;229(1):57–61. doi: 10.1007/BF00172262. [DOI] [PubMed] [Google Scholar]
- Jaffe G. J., Alvarado J. A., Juster R. P. Age-related changes of the normal visual field. Arch Ophthalmol. 1986 Jul;104(7):1021–1025. doi: 10.1001/archopht.1986.01050190079043. [DOI] [PubMed] [Google Scholar]
- Johnson C. A., Adams A. J., Lewis R. A. Evidence for a neural basis of age-related visual field loss in normal observers. Invest Ophthalmol Vis Sci. 1989 Sep;30(9):2056–2064. [PubMed] [Google Scholar]
- Jonas J. B., Gusek G. C., Naumann G. O. Optic disc, cup and neuroretinal rim size, configuration and correlations in normal eyes. Invest Ophthalmol Vis Sci. 1988 Jul;29(7):1151–1158. [PubMed] [Google Scholar]
- Jonas J. B., Schmidt A. M., Müller-Bergh J. A., Schlötzer-Schrehardt U. M., Naumann G. O. Human optic nerve fiber count and optic disc size. Invest Ophthalmol Vis Sci. 1992 May;33(6):2012–2018. [PubMed] [Google Scholar]
- Mikelberg F. S., Drance S. M., Schulzer M., Yidegiligne H. M., Weis M. M. The normal human optic nerve. Axon count and axon diameter distribution. Ophthalmology. 1989 Sep;96(9):1325–1328. doi: 10.1016/s0161-6420(89)32718-7. [DOI] [PubMed] [Google Scholar]
- Mikelberg F. S., Yidegiligne H. M., White V. A., Schulzer M. Relation between optic nerve axon number and axon diameter to scleral canal area. Ophthalmology. 1991 Jan;98(1):60–63. doi: 10.1016/s0161-6420(91)32341-8. [DOI] [PubMed] [Google Scholar]
- Nicolela M. T., Drance S. M. Various glaucomatous optic nerve appearances: clinical correlations. Ophthalmology. 1996 Apr;103(4):640–649. doi: 10.1016/s0161-6420(96)30640-4. [DOI] [PubMed] [Google Scholar]
- Pashby R. C., MacDonald R. K. Photographic assessment of the optic disc. Can J Ophthalmol. 1975 Apr;10(2):286–289. [PubMed] [Google Scholar]
- Quigley H. A., Brown A. E., Morrison J. D., Drance S. M. The size and shape of the optic disc in normal human eyes. Arch Ophthalmol. 1990 Jan;108(1):51–57. doi: 10.1001/archopht.1990.01070030057028. [DOI] [PubMed] [Google Scholar]
- Repka M. X., Quigley H. A. The effect of age on normal human optic nerve fiber number and diameter. Ophthalmology. 1989 Jan;96(1):26–32. doi: 10.1016/s0161-6420(89)32928-9. [DOI] [PubMed] [Google Scholar]
- Rohrschneider K., Burk R. O., Kruse F. E., Völcker H. E. Reproducibility of the optic nerve head topography with a new laser tomographic scanning device. Ophthalmology. 1994 Jun;101(6):1044–1049. doi: 10.1016/s0161-6420(94)31220-6. [DOI] [PubMed] [Google Scholar]
- Schwartz J. T., Reuling F. H., Garrison R. J. Acquired cupping of the optic nerve head in normotensive eyes. Br J Ophthalmol. 1975 Apr;59(4):216–222. doi: 10.1136/bjo.59.4.216. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sommer A., Pollack I., Maumenee A. E. Optic disc parameters and onset of glaucomatous field loss. I. Methods and progressive changes in disc morphology. Arch Ophthalmol. 1979 Aug;97(8):1444–1448. doi: 10.1001/archopht.1979.01020020106002. [DOI] [PubMed] [Google Scholar]
- Spencer A. F., Vernon S. A. Optic disc measurement: a comparison of indirect ophthalmoscopic methods. Br J Ophthalmol. 1995 Oct;79(10):910–915. doi: 10.1136/bjo.79.10.910. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tsai C. S., Ritch R., Shin D. H., Wan J. Y., Chi T. Age-related decline of disc rim area in visually normal subjects. Ophthalmology. 1992 Jan;99(1):29–35. doi: 10.1016/s0161-6420(92)32017-2. [DOI] [PubMed] [Google Scholar]
- Varma R., Tielsch J. M., Quigley H. A., Hilton S. C., Katz J., Spaeth G. L., Sommer A. Race-, age-, gender-, and refractive error-related differences in the normal optic disc. Arch Ophthalmol. 1994 Aug;112(8):1068–1076. doi: 10.1001/archopht.1994.01090200074026. [DOI] [PubMed] [Google Scholar]
- Woon W. H., Fitzke F. W., Bird A. C., Marshall J. Confocal imaging of the fundus using a scanning laser ophthalmoscope. Br J Ophthalmol. 1992 Aug;76(8):470–474. doi: 10.1136/bjo.76.8.470. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zeyen T. G., Caprioli J. Progression of disc and field damage in early glaucoma. Arch Ophthalmol. 1993 Jan;111(1):62–65. doi: 10.1001/archopht.1993.01090010066028. [DOI] [PubMed] [Google Scholar]