Figure 1  .

Slit lamp photographs of the corneas of affected family members in case 1. Top left, the proband at age 10 years before surgery (IV-10). Top right, the proband's brother at 21 years of age (IV-9). Second row left, the proband's father at 46 years (III-6). Second row right, the proband's mother at 48 years (III-5). Bottom left, the proband 9 year after the first surgery. Bottom right, Pedigree of the family of case 1. The genotype with regard to the R124H mutation in the BIGH3 gene is indicated: +/+, homozygous mutation; +/−, heterozygous mutation; −/−, wild type.