Figure 1  .

Targets for molecular therapy. TGF-β activity can be inhibited in several ways using different molecular approaches. Therapy may be directed against TGF-β and receptor proteins using fully human neutralising monoclonal antibodies. Alternatively, inhibition of TGF-β and receptors at the level of gene expression is possible using antisense oligonucleotides or ribozymes, which act at the level of messenger RNA (mRNA) and prevent protein synthesis.