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. 1988 Jun;32(6):886–889. doi: 10.1128/aac.32.6.886

Activity of amikacin against Mycobacterium avium complex under simulated in vivo conditions.

P R Gangadharam 1, L Kesavalu 1, P N Rao 1, V K Perumal 1, M D Iseman 1
PMCID: PMC172301  PMID: 3415209

Abstract

We studied the activity of amikacin against Mycobacterium avium complex strain 101 by using continuous-level, changing concentrations which simulated levels in serum in a patient, and pulsed exposures. Amikacin at a concentration of 5 or 15 micrograms/ml showed rapid bactericidal action following constant exposure of the organisms. With the in vitro model, using a peak concentration of 10 or 20 micrograms/ml, complete sterilization was obtained by day 7. In pulsed-exposure studies, a minimum period of contact of 72 or 96 h at a concentration of 10 micrograms/ml was needed for complete sterilization.

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Selected References

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