Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1988 Jun;32(6):925–927. doi: 10.1128/aac.32.6.925

Antibacterial characteristics of YTR 830, a sulfone beta-lactamase inhibitor, compared with those of clavulanic acid and sulbactam.

F Moosdeen 1, J D Williams 1, S Yamabe 1
PMCID: PMC172308  PMID: 2843088

Abstract

The antibacterial activity, binding to penicillin-binding proteins, and morphological changes effected by YTR 830, a sulfone beta-lactamase inhibitor, were studied in comparison with those of other beta-lactamase inhibitors. YTR 830 had very poor antibacterial activity, bound to PBP 2 of gram-negative organisms, and at the MIC caused rapid lysis of spheroplasts formed.

Full text

PDF

Images in this article

926Image
on p.926

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aronoff S. C., Jacobs M. R., Johenning S., Yamabe S. Comparative activities of the beta-lactamase inhibitors YTR 830, sodium clavulanate, and sulbactam combined with amoxicillin or ampicillin. Antimicrob Agents Chemother. 1984 Oct;26(4):580–582. doi: 10.1128/aac.26.4.580. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bonner W. M., Laskey R. A. A film detection method for tritium-labelled proteins and nucleic acids in polyacrylamide gels. Eur J Biochem. 1974 Jul 1;46(1):83–88. doi: 10.1111/j.1432-1033.1974.tb03599.x. [DOI] [PubMed] [Google Scholar]
  3. Bush K., Smith S. A., Ohringer S., Tanaka S. K., Bonner D. P. Improved sensitivity in assays for binding of novel beta-lactam antibiotics to penicillin-binding proteins of Escherichia coli. Antimicrob Agents Chemother. 1987 Aug;31(8):1271–1273. doi: 10.1128/aac.31.8.1271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Curtis N. A., Orr D., Ross G. W., Boulton M. G. Affinities of penicillins and cephalosporins for the penicillin-binding proteins of Escherichia coli K-12 and their antibacterial activity. Antimicrob Agents Chemother. 1979 Nov;16(5):533–539. doi: 10.1128/aac.16.5.533. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Garcia I., Fainstein V., LeBlanc B., Bodey G. P. In vitro activities of new beta-lactam antibiotics against Acinetobacter spp. Antimicrob Agents Chemother. 1983 Aug;24(2):297–299. doi: 10.1128/aac.24.2.297. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Greenwood D., Eley A. In-vitro evaluation of sulbactam, a penicillanic acid sulphone with beta-lactamase inhibitory properties. J Antimicrob Chemother. 1982 Aug;10(2):117–123. doi: 10.1093/jac/10.2.117. [DOI] [PubMed] [Google Scholar]
  7. Gutmann L., Kitzis M. D., Yamabe S., Acar J. F. Comparative evaluation of a new beta-lactamase inhibitor, YTR 830, combined with different beta-lactam antibiotics against bacteria harboring known beta-lactamases. Antimicrob Agents Chemother. 1986 May;29(5):955–957. doi: 10.1128/aac.29.5.955. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  9. Labia R., Baron P., Masson J. M., Hill G., Cole M. Affinity of temocillin for Escherichia coli K-12 penicillin-binding proteins. Antimicrob Agents Chemother. 1984 Sep;26(3):335–338. doi: 10.1128/aac.26.3.335. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Laemmli U. K., Favre M. Maturation of the head of bacteriophage T4. I. DNA packaging events. J Mol Biol. 1973 Nov 15;80(4):575–599. doi: 10.1016/0022-2836(73)90198-8. [DOI] [PubMed] [Google Scholar]
  11. Spratt B. G., Pardee A. B. Penicillin-binding proteins and cell shape in E. coli. Nature. 1975 Apr 10;254(5500):516–517. doi: 10.1038/254516a0. [DOI] [PubMed] [Google Scholar]
  12. Spratt B. G. Properties of the penicillin-binding proteins of Escherichia coli K12,. Eur J Biochem. 1977 Jan;72(2):341–352. doi: 10.1111/j.1432-1033.1977.tb11258.x. [DOI] [PubMed] [Google Scholar]
  13. Yourassowsky E., Van der Linden M. P., Lismont M. J., Crokaert F. Growth curve patterns and bacterial morphology of Escherichia coli subjected to different temocillin (BRL 17421) concentrations. J Antimicrob Chemother. 1982 Oct;10(4):289–293. doi: 10.1093/jac/10.4.289. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES