Table 1.

Decreased susceptibility to bicuculline methiodide-induced seizures in transgenic mice overexpressing the human soluble form of IL-1Ra in astrocytes (GILRA2)

	No mice with seizures		Onset, min		Duration, min
	Clonic	Tonic	Clonus	Tonus	Clonus	Tonus
Wild type	11/11	11/11	2.9  ± 0.4	6.9  ± 1.3	68.9  ± 4.2	2.9  ± 0.7
GILRA2	7/7	4/7*	2.5  ± 0.5	44.7  ± 16†	22.4  ± 7.9†	0.7  ± 0.3‡

Data are the mean ± S.E.M. Fractions represent the number of B6/CBA mice showing clonic or tonic seizures on the total number of mice. Bicuculline methiodide was injected at a dose of 0.24 nmol in 0.5 μl unilaterally in the dorsal hippocampus. The onset of tonus was reckoned as 90 min (total observation time) in the mice not showing this behavior (n = 3). A significantly lower number of mice overexpressing IL-1Ra (GILRA2) showed tonic convulsions after bicuculline. These mice showed a significant reduction in the duration of generalized seizures.  

^‡, P < 0.05,  

^†, P < 0.01 by Student's t test; *, P < 0.05 by Fisher's test vs. wild-type littermate controls injected with bicuculline (wild type). Representative EEG recordings of ictal and interictal activity are shown in Fig. 3.