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Melatonin levels ± SEM measured in pineal explants cultured for 5, 7, and 9 days (n = 19 cultures for each treatment). Melatonin levels were measured at the end of a 6-h period of stimulation with 10 μM NE, during which the explants were exposed either to light (open bars) or dark (solid bars). * denotes P < 0.05; ** P < 0.01.
