Figure 4.

(A) Regenerative abilities of sensory axons in the sciatic nerve after a crush injury were measured by using the pinch test. Mutant mice showed statistically reduced rates of regeneration compared with the wild-type control group at all time points (t test; *, P < 0.05; ***, P < 0.001, n = 8). Data are presented as regeneration distance (mm) ± SEM. (B) Long-term functional recovery after a crush injury to the sciatic nerve measured by using the toe spreading index. Mutant mice showed statistically reduced rates of regeneration compared with the wild-type control group at weeks 2–4 (t test; *, P < 0.05; **, P < 0.01, n = 8). Data are presented as percentage recovery compared with the uninjured foot ± SEM.