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. 2000 Oct 3;97(21):11569–11574. doi: 10.1073/pnas.210254597

Figure 3.

Figure 3

(A) The effect of 40-min perfusion of 1 μM scopolamine on ACh release in the hippocampus of wild-type and mutant animals at 4 months of age was studied. No significant differences in stimulated extracellular ACh levels were noted in the wild-type and mutant groups (n = 6). In both groups, the released ACh slowly returned to the basal values within 80–100 min. (B) In the 10-month-old animals, scopolamine-evoked ACh release was significantly attenuated in the mutants compared with wild-type age-matched controls (t test, **P < 0.01; n = 5). (C) Similarly, the area under the curve (AUC 0–120 min) values was not significantly different between the genotypes at 4 months of age but was reduced by 47% in the 10-month-old animals (t test, **P < 0.01; n = 5).