Figure 4.
Representative profiles of locomotor activity in VPAC2R transgenic and wild-type mice. Records are double-plotted so that 48 h are shown for each horizontal trace and consecutive days are aligned vertically and duplicated diagonally. Periods of darkness are shaded. For the first 6 days, animals were exposed to a 12:12 h light:dark (LD) cycle (dark from 19:00 to 07:00). On day 7, the LD cycle was advanced by 8 h (dark from 11:00 to 23:00) via a shortened light period of four hours. On day 17, the LD cycle was returned to the original lighting regime (dark 19:00 to 07:00) via a light period of 20 h. From day 30, animals were maintained in constant darkness.