Figure 1.

Sensory neuron-specific sodium channel SNS is abnormally expressed in cerebellar Purkinje cells of mice with chronic relapsing EAE (a and b; two different mice). SNS mRNA signal was observed in all mice with EAE after hybridization with each of two SNS-specific antisense riboprobes [SNS-3′-untranslated region riboprobe (a); SNS riboprobe (b); n = 3 for each probe). SNS mRNA signal was not detectable in cerebellums from control mice (n = 3) (c) or after hybridization with sense riboprobes (d). (a, ×120; b–d, ×200.)