Figure 3.

SNS mRNA is abnormally expressed in cerebellar Purkinje cells from brains obtained postmortem from patients with MS. A distinct SNS hybridization signal is present in Purkinje cells from two subjects with MS (a and b) after hybridization with a riboprobe specific for human SNS mRNA, but it was not detectable in tissue obtained from control subjects without neurological disease (c). No SNS hybridization signal is detectable in MS cerebellum after hybridization with sense riboprobe (d). (a, ×95; Inset, ×230; b–d, ×130.)