Figure 2 .

(A) In needle biopsy samples signs of biliary cirrhosis were prominent at six years of age (haematoxylin-eosin staining). (B) Following immunostaining of the liver there was intensive reaction with antihuman immunoglobulin predominantly on the surface of the hepatocytes. (C) Hepatocytes did not show binding of antimouse immunoglobulins (haematoxylin nuclear staining background; the yellow areas are from the bile pigments). (D) The hepatocytes of an adult patient who had died of alcoholic cirrhosis did not bind human immunoglobulins.